biostudies-literatureWang RBasic and Applied Research Foundation of Guangdong Province, ChinaGuangzhou Science and Technology ProjectScience and Technology Basic and Applied Basic Research Project of GuangzhouNational Natural Science Foundation of ChinaNational Natural Science Foundation of China40https://www.ebi.ac.uk/biostudies/studies/S-EPMC10910709biostudies-literatureUnknown19(1)<h4>Background</h4>Pyroptosis has been demonstrated being closely associated with the inflammatory progression in chronic rhinosinusitis (CRS). However, platycodon D (PLD) has emerged as a key anti-inflammatory mediator in the inflammatory progression of various respiratory diseases. This study aims at investigating whether PLD could reduce inflammatory progression of CRS by inhibiting pyroptosis.<h4>Methods</h4>Nasal mucosal tissues from patients with CRS and the control group (simple nasal septal deviation) were analyzed for morphological difference using hematoxylin & eosin staining and for the expression of pyroptosis-related makers by immunofluorescence (IF). Human nasal epithelial cells (HNEpCs) were cultured and co-stimulated with lipopolysaccharide (LPS)/adenosine triphosphate (ATPChinese medicinePlatycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis.PMC1091070920220101121182305325819745812022-01-01-11-3016-0012822745902021A1515110446Liu HZhou MRuan YZhu JWang RHe WLu ZFang CWang YYan YXu WfalsePlatycodon D protects human nasal epithelial cells from pyroptosis through the Nrf2/HO-1/ROS signaling cascade in chronic rhinosinusitis.<h4>Background</h4>Pyroptosis has been demonstrated being closely associated with the inflammatory progression in chronic rhinosinusitis (CRS). However, platycodon D (PLD) has emerged as a key anti-inflammatory mediator in the inflammatory progression of various respiratory diseases. This study aims at investigating whether PLD could reduce inflammatory progression of CRS by inhibiting pyroptosis.<h4>Methods</h4>Nasal mucosal tissues from patients with CRS and the control group (simple nasal septal deviation) were analyzed for morphological difference using hematoxylin & eosin staining and for the expression of pyroptosis-related makers by immunofluorescence (IF). Human nasal epithelial cells (HNEpCs) were cultured and co-stimulated with lipopolysaccharide (LPS)/adenosine triphosphate (ATP2024-01-01T00:00:00Z2024 Mar2025-04-05T11:39:09.521Z2025-04-05T11:39:09.521ZS-EPMC109107093843321610.1186/s13020-024-00897-y