{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2"],"submitter":["Veldhuis N"],"pubmed_abstract":["<h4>Objective</h4>To evaluate the prevalence, type and extent of linguistic spin in randomized controlled trials (RCTs) exploring interventions in patients with age-related macular degeneration (AMD), as well as to investigate whether study variables were correlated with linguistic spin.<h4>Study design and setting</h4>PubMed was searched from 2011 to 2020 to identify RCTs including patients with AMD. Two authors independently assessed a total of 96 RCTs. Linear regression analyses were performed to investigate whether linguistic spin was correlated with predefined study variables.<h4>Results</h4>Linguistic spin was found in 61 of 96 abstracts (63.5%) and in 90 of 96 main texts (93.8%). Use of words pointing out the beneficial effect of a treatment and the use of '(statistically) significant/significance' without reporting a <i>P</i>-value or a 95% confidence interval (CI) were the most frequently identified categories of linguistic spin. Sample size was significantly correlated with the total linguistic spin score (95% CI 0.38-5.23, <i>P</i> = 0.02).<h4>Conclusion</h4>A high prevalence and extent of linguistic spin in RCTs about AMD was found. We highlighted the importance of objective reporting and awareness of linguistic spin among ophthalmologists and other readers."],"journal":["Frontiers in epidemiology"],"pagination":["961996"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10910936"],"repository":["biostudies-literature"],"pubmed_title":["Linguistic spin in randomized controlled trials about age-related macular degeneration."],"pmcid":["PMC10910936"],"pubmed_authors":["Stegeman I","Isphording L","Lee-Kong FVYL","Nuijts MA","Veldhuis N","Imhof SM"],"additional_accession":[]},"is_claimable":false,"name":"Linguistic spin in randomized controlled trials about age-related macular degeneration.","description":"<h4>Objective</h4>To evaluate the prevalence, type and extent of linguistic spin in randomized controlled trials (RCTs) exploring interventions in patients with age-related macular degeneration (AMD), as well as to investigate whether study variables were correlated with linguistic spin.<h4>Study design and setting</h4>PubMed was searched from 2011 to 2020 to identify RCTs including patients with AMD. Two authors independently assessed a total of 96 RCTs. Linear regression analyses were performed to investigate whether linguistic spin was correlated with predefined study variables.<h4>Results</h4>Linguistic spin was found in 61 of 96 abstracts (63.5%) and in 90 of 96 main texts (93.8%). Use of words pointing out the beneficial effect of a treatment and the use of '(statistically) significant/significance' without reporting a <i>P</i>-value or a 95% confidence interval (CI) were the most frequently identified categories of linguistic spin. Sample size was significantly correlated with the total linguistic spin score (95% CI 0.38-5.23, <i>P</i> = 0.02).<h4>Conclusion</h4>A high prevalence and extent of linguistic spin in RCTs about AMD was found. We highlighted the importance of objective reporting and awareness of linguistic spin among ophthalmologists and other readers.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T12:35:19.276Z","creation":"2025-04-04T12:35:19.276Z"},"accession":"S-EPMC10910936","cross_references":{"pubmed":["38455287"],"doi":["10.3389/fepid.2022.961996"]}}