{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Doro D"],"funding":["King's College London","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","Medical Research Council","Ministry of Education, Culture, Sports, Science and Technology","Biotechnology and Biological Sciences Research Council and the Medical Research Council","Biotechnology and Biological Sciences Research Council","Japan Society for the Promotion of Science"],"pagination":["dev202116"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10911112"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["151(3)"],"pubmed_abstract":["The cranial sutures are proposed to be a stem cell niche, harbouring skeletal stem cells that are directly involved in development, homeostasis and healing. Like the craniofacial bones, the sutures are formed from both mesoderm and neural crest. During cranial bone repair, neural crest cells have been proposed to be key players; however, neural crest contributions to adult sutures are not well defined, and the relative importance of suture proximity is unclear. Here, we use genetic approaches to re-examine the neural crest-mesoderm boundaries in the adult mouse skull. These are combined with calvarial wounding experiments suggesting that suture proximity improves the efficiency of cranial repair. Furthermore, we demonstrate that Gli1+ and Axin2+ skeletal stem cells are present in all calvarial sutures examined. We propose that the position of the defect determines the availability of neural crest-derived progenitors, which appear to be a key element in the repair of calvarial defects."],"journal":["Development (Cambridge, England)"],"pubmed_title":["Cranial suture lineage and contributions to repair of the mouse skull."],"pmcid":["PMC10911112"],"funding_grant_id":["PC21044","21H03098","BB/R015953/1","BB/I021922/1"],"pubmed_authors":["Krstic M","Rajendran AK","Lau JS","Doro D","Healy C","Liu A","Iseki S","Liu KJ","Grigoriadis AE"],"additional_accession":[]},"is_claimable":false,"name":"Cranial suture lineage and contributions to repair of the mouse skull.","description":"The cranial sutures are proposed to be a stem cell niche, harbouring skeletal stem cells that are directly involved in development, homeostasis and healing. Like the craniofacial bones, the sutures are formed from both mesoderm and neural crest. During cranial bone repair, neural crest cells have been proposed to be key players; however, neural crest contributions to adult sutures are not well defined, and the relative importance of suture proximity is unclear. Here, we use genetic approaches to re-examine the neural crest-mesoderm boundaries in the adult mouse skull. These are combined with calvarial wounding experiments suggesting that suture proximity improves the efficiency of cranial repair. Furthermore, we demonstrate that Gli1+ and Axin2+ skeletal stem cells are present in all calvarial sutures examined. We propose that the position of the defect determines the availability of neural crest-derived progenitors, which appear to be a key element in the repair of calvarial defects.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-05T11:38:44.805Z","creation":"2025-04-05T11:38:44.805Z"},"accession":"S-EPMC10911112","cross_references":{"pubmed":["38345329"],"doi":["10.1242/dev.202116"]}}