{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["37"],"submitter":["Grasberger J"],"pubmed_abstract":["The total burden of infections after transplantation has not been compared in detail between recipients of simultaneous pancreas-kidney transplantation (SPK) and kidney transplantation alone (KTA). We compared infection-related hospitalizations and bacteremias after transplantation during 1- and 5-year follow-up among 162 patients undergoing SPK. The control group consisted of 153 type 1 diabetics undergoing KTA with the inclusion criteria of donor and recipient age < 60, and BMI < 30. During the first year, SPK patients had more infection-related hospitalizations (0.54 vs. 0.31 PPY, IRR 1.76, <i>p</i> = <0.001) and bacteremias (0.11 vs. 0.01 PPY, IRR 17.12, <i>p</i> = <0.001) compared to KTA patients. The first infection-related hospitalizations and bacteremias occurred later during follow-up in KTA patients. SPK was an independent risk factor for infection-related hospitalization and bacteremia during the first year after transplantation, but not during the 5-year follow-up. Patient survival did not differ between groups, however, KTA patients had inferior kidney graft survival. SPK patients are at greater risk for infection-related hospitalizations and bacteremias during the first year after transplantation compared to KTA patients, however, at the end of the follow-up the risk of infection was similar between groups."],"journal":["Transplant international : official journal of the European Society for Organ Transplantation"],"pagination":["12235"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10912468"],"repository":["biostudies-literature"],"pubmed_title":["Infection-Related Hospitalizations After Simultaneous Pancreas-Kidney Transplantation Compared to Kidney Transplantation Alone."],"pmcid":["PMC10912468"],"pubmed_authors":["Ortiz F","Finne P","Ahopelto K","Gissler M","Helantera I","Grasberger J","Lempinen M","Sallinen V","Ekstrand A"],"additional_accession":[]},"is_claimable":false,"name":"Infection-Related Hospitalizations After Simultaneous Pancreas-Kidney Transplantation Compared to Kidney Transplantation Alone.","description":"The total burden of infections after transplantation has not been compared in detail between recipients of simultaneous pancreas-kidney transplantation (SPK) and kidney transplantation alone (KTA). We compared infection-related hospitalizations and bacteremias after transplantation during 1- and 5-year follow-up among 162 patients undergoing SPK. The control group consisted of 153 type 1 diabetics undergoing KTA with the inclusion criteria of donor and recipient age < 60, and BMI < 30. During the first year, SPK patients had more infection-related hospitalizations (0.54 vs. 0.31 PPY, IRR 1.76, <i>p</i> = <0.001) and bacteremias (0.11 vs. 0.01 PPY, IRR 17.12, <i>p</i> = <0.001) compared to KTA patients. The first infection-related hospitalizations and bacteremias occurred later during follow-up in KTA patients. SPK was an independent risk factor for infection-related hospitalization and bacteremia during the first year after transplantation, but not during the 5-year follow-up. Patient survival did not differ between groups, however, KTA patients had inferior kidney graft survival. SPK patients are at greater risk for infection-related hospitalizations and bacteremias during the first year after transplantation compared to KTA patients, however, at the end of the follow-up the risk of infection was similar between groups.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-17T06:31:37.363Z","creation":"2026-06-17T03:06:57.631Z"},"accession":"S-EPMC10912468","cross_references":{"pubmed":["38444997"],"doi":["10.3389/ti.2024.12235"]}}