biostudies-literatureUnknown15Placa DR<h4>Introduction</h4>Dengue virus infection is a global health problem lacking specific therapy, requiring an improved understanding of DENV immunity and vaccine responses. Considering the recent emerging of new dengue vaccines, here we performed an integrative systems vaccinology characterization of molecular signatures triggered by the natural DENV infection (NDI) and attenuated dengue virus infection models (DVTs).<h4>Methods and results</h4>We analyzed 955 samples of transcriptomic datasets of patients with NDI and attenuated dengue virus infection trials (DVT1, DVT2, and DVT3) using a systems vaccinology approach. Differential expression analysis identified 237 common differentially expressed genes (DEGs) between DVTs and NDI. Among them, 28 and 60 DEGs were up or downregulated by denFrontiers in immunology1282754https://www.ebi.ac.uk/biostudies/studies/S-EPMC10912564biostudies-literatureImmunological signatures unveiled by integrative systems vaccinology characterization of dengue vaccination trials and natural infection.PMC10912564Fonseca DLMCamara NOSCatar RZaki Pour SSchimke LFPrado CASCabral-Miranda GCabral-Marques OFreire PPPlaca DRRivino LUsuda JNBaiocchi GCSalgado RCJurisica IOchs HDFilgueiras ISRocha VCalich VLGGiil LMMoll GMarques AHCfalseImmunological signatures unveiled by integrative systems vaccinology characterization of dengue vaccination trials and natural infection.<h4>Introduction</h4>Dengue virus infection is a global health problem lacking specific therapy, requiring an improved understanding of DENV immunity and vaccine responses. Considering the recent emerging of new dengue vaccines, here we performed an integrative systems vaccinology characterization of molecular signatures triggered by the natural DENV infection (NDI) and attenuated dengue virus infection models (DVTs).<h4>Methods and results</h4>We analyzed 955 samples of transcriptomic datasets of patients with NDI and attenuated dengue virus infection trials (DVT1, DVT2, and DVT3) using a systems vaccinology approach. Differential expression analysis identified 237 common differentially expressed genes (DEGs) between DVTs and NDI. Among them, 28 and 60 DEGs were up or downregulated by den2024-01-01T00:00:00Z20242026-06-09T07:02:01.545Z2026-06-09T03:12:18.493ZS-EPMC109125643844485110.3389/fimmu.2024.1282754