{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(2)"],"submitter":["Pannu AK"],"pubmed_abstract":["<h4>Introduction</h4>Despite the widespread use of antivenom for the treatment of snakebite envenoming in the Indian subcontinent, the ideal dose of antivenom has been a point of contention. Low-dose regimens can economize on a scarce resource in low- and middle-income countries. This study assessed the effectiveness of a low-dose (10 vials) antivenom regimen compared to the usual 20 vials in patients with krait bite neuroparalysis requiring mechanical ventilation.<h4>Methods</h4>This study was a prospective controlled pilot study conducted in a tertiary-care hospital in north India. Participants were eligible if they were ≥12 years old, had krait bite neurotoxicity, showed severe paralysis requiring mechanical ventilation, and had access to antivenom therapy within 24 h of the bite. The p"],"journal":["Toxicology research"],"pagination":["tfae023"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10913380"],"repository":["biostudies-literature"],"pubmed_title":["Efficacy of a low dose of antivenom for severe neuroparalysis in &lt;i&gt;Bungarus caeruleus&lt;/i&gt; (common krait) envenomation: a pilot study."],"pmcid":["PMC10913380"],"pubmed_authors":["Dhibar DP","Pannu AK","Chand D","Bhalla A"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy of a low dose of antivenom for severe neuroparalysis in &lt;i&gt;Bungarus caeruleus&lt;/i&gt; (common krait) envenomation: a pilot study.","description":"<h4>Introduction</h4>Despite the widespread use of antivenom for the treatment of snakebite envenoming in the Indian subcontinent, the ideal dose of antivenom has been a point of contention. Low-dose regimens can economize on a scarce resource in low- and middle-income countries. This study assessed the effectiveness of a low-dose (10 vials) antivenom regimen compared to the usual 20 vials in patients with krait bite neuroparalysis requiring mechanical ventilation.<h4>Methods</h4>This study was a prospective controlled pilot study conducted in a tertiary-care hospital in north India. Participants were eligible if they were ≥12 years old, had krait bite neurotoxicity, showed severe paralysis requiring mechanical ventilation, and had access to antivenom therapy within 24 h of the bite. The p","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-03T23:32:29.479Z","creation":"2025-04-03T23:32:29.479Z"},"accession":"S-EPMC10913380","cross_references":{"pubmed":["38450179"],"doi":["10.1093/toxres/tfae023"]}}