biostudies-literatureUnknown13(2)Pannu AK<h4>Introduction</h4>Despite the widespread use of antivenom for the treatment of snakebite envenoming in the Indian subcontinent, the ideal dose of antivenom has been a point of contention. Low-dose regimens can economize on a scarce resource in low- and middle-income countries. This study assessed the effectiveness of a low-dose (10 vials) antivenom regimen compared to the usual 20 vials in patients with krait bite neuroparalysis requiring mechanical ventilation.<h4>Methods</h4>This study was a prospective controlled pilot study conducted in a tertiary-care hospital in north India. Participants were eligible if they were ≥12 years old, had krait bite neurotoxicity, showed severe paralysis requiring mechanical ventilation, and had access to antivenom therapy within 24 h of the bite. The pToxicology researchtfae023https://www.ebi.ac.uk/biostudies/studies/S-EPMC10913380biostudies-literatureEfficacy of a low dose of antivenom for severe neuroparalysis in &lt;i&gt;Bungarus caeruleus&lt;/i&gt; (common krait) envenomation: a pilot study.PMC10913380Dhibar DPPannu AKChand DBhalla AfalseEfficacy of a low dose of antivenom for severe neuroparalysis in &lt;i&gt;Bungarus caeruleus&lt;/i&gt; (common krait) envenomation: a pilot study.<h4>Introduction</h4>Despite the widespread use of antivenom for the treatment of snakebite envenoming in the Indian subcontinent, the ideal dose of antivenom has been a point of contention. Low-dose regimens can economize on a scarce resource in low- and middle-income countries. This study assessed the effectiveness of a low-dose (10 vials) antivenom regimen compared to the usual 20 vials in patients with krait bite neuroparalysis requiring mechanical ventilation.<h4>Methods</h4>This study was a prospective controlled pilot study conducted in a tertiary-care hospital in north India. Participants were eligible if they were ≥12 years old, had krait bite neurotoxicity, showed severe paralysis requiring mechanical ventilation, and had access to antivenom therapy within 24 h of the bite. The p2024-01-01T00:00:00Z2024 Apr2025-04-03T23:32:29.479Z2025-04-03T23:32:29.479ZS-EPMC109133803845017910.1093/toxres/tfae023