{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Angelovich TA"],"funding":["NIDA NIH HHS","NIMH NIH HHS","National Health and Medical Research Council","NCI NIH HHS","National Institute on Drug Abuse"],"pagination":["798-802"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10914117"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["94(4)"],"pubmed_abstract":["Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH) harbored HIV pol DNA in all regions tested, with lower levels present in basal ganglia and cerebellum relative to frontal white matter. Intact proviruses were primarily found in the frontal white matter but also detected in other brain regions of PWH, demonstrating frontal white matter as a major brain reservoir of intact, potentially replication competent HIV DNA that persists despite antiretroviral therapy. ANN NEUROL 2023;94:798-802."],"journal":["Annals of neurology"],"pubmed_title":["Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV."],"pmcid":["PMC10914117"],"funding_grant_id":["U24 MH100929","R21DA055489","U24 MH100928","HHSN261201500003I","U24 MH100931","75N91019D00024","HHSN261201500003C","U24 MH100930","U24 MH100925","R21 DA055489","1183032"],"pubmed_authors":["Angelovich TA","Turville S","Byrnes SJ","Lewin SR","Churchill MJ","Hearps AC","Busman-Sahay K","Tumpach C","Deleage C","Brew BJ","Jenkins TA","Jamal Eddine J","Cochrane CR","Estes JD","Waring E","Gorry PR","Roche M","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV.","description":"Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH) harbored HIV pol DNA in all regions tested, with lower levels present in basal ganglia and cerebellum relative to frontal white matter. Intact proviruses were primarily found in the frontal white matter but also detected in other brain regions of PWH, demonstrating frontal white matter as a major brain reservoir of intact, potentially replication competent HIV DNA that persists despite antiretroviral therapy. ANN NEUROL 2023;94:798-802.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Oct","modification":"2024-12-04T03:24:54.813Z","creation":"2024-12-04T03:24:54.813Z"},"accession":"S-EPMC10914117","cross_references":{"pubmed":["37493435"],"doi":["10.1002/ana.26750"]}}