biostudies-literatureCho SMLiverpool Experimental Cancer Medicine CentreNHLBI NIH HHSNational Heart, Lung, and Blood InstituteMetro-North Clinical Research FellowshipFrench Ministry of HealthAustralian Government Department of HealthEuropean Clinical Research Alliance on Infectious DiseasesBill & Melinda Gates FoundationREACTingUK Foreign, Commonwealth and Development OfficeUniversity of Oxford’s COVID-19 Research Response FundMedical Research CouncilResearch Council of NorwayNational Institute for Health Research (NIHR)Seventh Framework ProgrammeAdvance Queensland Industry Research FellowshipWellcome TrustBiotechnology and Biological Sciences Research Councilfcae036https://www.ebi.ac.uk/biostudies/studies/S-EPMC10914448biostudies-literatureUnknown6(2)Although it is known that coronavirus disease 2019 can present with a range of neurological manifestations and in-hospital complications, sparse data exist on whether these initial neurological symptoms of coronavirus disease 2019 are closely associated with post-acute neurological sequelae of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2; PANSC) and whether female versus male sex impacts symptom resolution. In this international, multi-centre, prospective, observational study across 407 sites from 15 countries (30 January 2020 to 30 April 2022), we report the prevalence and risk factors of PANSC among hospitalized adults and investigate the differences between males and females on neurological symptom resolution over time. PANSC symptoms included altered consciousness/confusBrain communicationsSex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study.PMC10914448220757/Z/20/Z3273191NIHR2033120009109FP7/2007-2013225288/Z/22/Z3127801K23HL157610965313K23 HL157610BBS/E/D/30002277215091/Z/18/ZOPP1209135MC_PC_19059MR/S032304/1222410/Z/21/ZC18616/A25153CO-CIN-01AQIRF076-2020-CVLariviere DSancho-Shimizu VVuotto FGagnard JCFerriere NHamidfar RRoncon-Albuquerque RDucancelle AGoehringer FLeone MMcArthur CBattaglini DLevy YZabbe MLe Moal GOpenshaw PGranier PTimsit JFBolanos IDelacroix IArlet JBMurris MFletcher TSedillot NBadr CArtaud-Macari ECordel HReikvam DHLe Mestre SSibiude JDubos FMeta RDocherty ABIsnard MGriffee MSummers CWhite NCheret ADubee VAuchabie JKutsyna GBehilill SLevy BLaine FGorelik YManuel ABoureau ASPreau SReyes LFCastor-Alexandre GMahy SSuen 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Characterization GroupChenard LMergeay-Fabre MGarrait VAlex BHachemi APoissy JGirvan MSigfrid LGhosn JNguyen DBenech NJoseph CUyeki TMDenis ESotto AEnderle IfalseSex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study.Although it is known that coronavirus disease 2019 can present with a range of neurological manifestations and in-hospital complications, sparse data exist on whether these initial neurological symptoms of coronavirus disease 2019 are closely associated with post-acute neurological sequelae of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2; PANSC) and whether female versus male sex impacts symptom resolution. In this international, multi-centre, prospective, observational study across 407 sites from 15 countries (30 January 2020 to 30 April 2022), we report the prevalence and risk factors of PANSC among hospitalized adults and investigate the differences between males and females on neurological symptom resolution over time. PANSC symptoms included altered consciousness/confus2024-01-01T00:00:00Z20242026-06-01T11:22:59.728Z2025-04-06T12:35:01.296ZS-EPMC109144483844490710.1093/braincomms/fcae036