{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Jiang M"],"pubmed_abstract":["In the present study, a novel coordination polymer (CP) based on Ni(II), namely, [Ni(L)(D-CAM)(H<sub>2</sub>O)]<sub>n</sub> (1) (H<sub>2</sub>D-CAM = (1R,3S)-1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid and L = 3,6-bis(benzimidazol-1-yl)pyridazine), has been produced successfully through applying a mixed ligand synthesis method via reacting Ni(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O with 3,6-bis(benzimidazol-1-yl)pyridazine ligand in the presence of a carboxylic acid co-ligand. Hyaluronic acid (HA) and carboxymethyl chitosan (CMCS) are representatives of natural polysaccharides and have good biocompatibility. Based on the chemical synthesis method, HA/CMCS hydrogel was successfully prepared. SEM showed that the lyophilized gel presented a typical macroporous structure with three-d"],"journal":["Scientific reports"],"pagination":["5421"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10914818"],"repository":["biostudies-literature"],"pubmed_title":["Utilizing Ni(II) complex for metal drug-gel particles in cervical cancer treatment and designing novel drugs through machine learning methods."],"pmcid":["PMC10914818"],"pubmed_authors":["Wu R","Wang X","Jiang M","Liu D"],"additional_accession":[]},"is_claimable":false,"name":"Utilizing Ni(II) complex for metal drug-gel particles in cervical cancer treatment and designing novel drugs through machine learning methods.","description":"In the present study, a novel coordination polymer (CP) based on Ni(II), namely, [Ni(L)(D-CAM)(H<sub>2</sub>O)]<sub>n</sub> (1) (H<sub>2</sub>D-CAM = (1R,3S)-1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid and L = 3,6-bis(benzimidazol-1-yl)pyridazine), has been produced successfully through applying a mixed ligand synthesis method via reacting Ni(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O with 3,6-bis(benzimidazol-1-yl)pyridazine ligand in the presence of a carboxylic acid co-ligand. Hyaluronic acid (HA) and carboxymethyl chitosan (CMCS) are representatives of natural polysaccharides and have good biocompatibility. Based on the chemical synthesis method, HA/CMCS hydrogel was successfully prepared. SEM showed that the lyophilized gel presented a typical macroporous structure with three-d","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-05-29T22:03:37.883Z","creation":"2024-11-09T06:17:21.513Z"},"accession":"S-EPMC10914818","cross_references":{"pubmed":["38443412"],"doi":["10.1038/s41598-024-55897-7"]}}