biostudies-literatureUnknown14(1)Jiang MIn the present study, a novel coordination polymer (CP) based on Ni(II), namely, [Ni(L)(D-CAM)(H<sub>2</sub>O)]<sub>n</sub> (1) (H<sub>2</sub>D-CAM = (1R,3S)-1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid and L = 3,6-bis(benzimidazol-1-yl)pyridazine), has been produced successfully through applying a mixed ligand synthesis method via reacting Ni(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O with 3,6-bis(benzimidazol-1-yl)pyridazine ligand in the presence of a carboxylic acid co-ligand. Hyaluronic acid (HA) and carboxymethyl chitosan (CMCS) are representatives of natural polysaccharides and have good biocompatibility. Based on the chemical synthesis method, HA/CMCS hydrogel was successfully prepared. SEM showed that the lyophilized gel presented a typical macroporous structure with three-dScientific reports5421https://www.ebi.ac.uk/biostudies/studies/S-EPMC10914818biostudies-literatureUtilizing Ni(II) complex for metal drug-gel particles in cervical cancer treatment and designing novel drugs through machine learning methods.PMC10914818Wu RWang XJiang MLiu DfalseUtilizing Ni(II) complex for metal drug-gel particles in cervical cancer treatment and designing novel drugs through machine learning methods.In the present study, a novel coordination polymer (CP) based on Ni(II), namely, [Ni(L)(D-CAM)(H<sub>2</sub>O)]<sub>n</sub> (1) (H<sub>2</sub>D-CAM = (1R,3S)-1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid and L = 3,6-bis(benzimidazol-1-yl)pyridazine), has been produced successfully through applying a mixed ligand synthesis method via reacting Ni(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O with 3,6-bis(benzimidazol-1-yl)pyridazine ligand in the presence of a carboxylic acid co-ligand. Hyaluronic acid (HA) and carboxymethyl chitosan (CMCS) are representatives of natural polysaccharides and have good biocompatibility. Based on the chemical synthesis method, HA/CMCS hydrogel was successfully prepared. SEM showed that the lyophilized gel presented a typical macroporous structure with three-d2024-01-01T00:00:00Z2024 Mar2025-05-29T22:03:37.883Z2024-11-09T06:17:21.513ZS-EPMC109148183844341210.1038/s41598-024-55897-7