biostudies-literatureRadu RANINDS NIH HHS114-123https://www.ebi.ac.uk/biostudies/studies/S-EPMC10916815biostudies-literatureUnknown9(1)<h4>Introduction</h4>First pass effect (FPE), achievement of complete recanalization (mTICI 2c/3) with a single pass, is a significant predictor of favorable outcomes for endovascular treatment (EVT) in large vessel occlusion stroke (LVO). However, data concerning the impact on functional outcomes and predictors of FPE in medium vessel occlusions (MeVO) are scarce.<h4>Patients and methods</h4>We conducted an international retrospective study on MeVO cases. Multivariable logistic modeling was used to establish independent predictors of FPE. Clinical and safety outcomes were compared between the two study groups (FPE vs non-FPE) using logistic regression models. Good outcome was defined as modified Rankin Scale 0-2 at 3 months.<h4>Results</h4>Eight hundred thirty-six patients with a final mTEuropean stroke journalFirst pass effect as an independent predictor of functional outcomes in medium vessel occlusions: An analysis of an international multicenter study.PMC10916815R21 NS131756Paul Stracke CPedicelli ADofuku SGriessenauer CJPremat KHarker PCostalat VMohlenbruch MACapirossi CVarela RRegenhardt RWBarreau XLiebeskind DSYedavalli VHsieh CYWeyland CMounayer CFahed RMartinez-Gutierrez JCQuintero-Consuegra MSibon IMowla AKiller-Oberpfalzer MPuri ASRabinov JDFaizy TDPereira VMShaikh HSweid AMeyer LKhalife JBiswas ASalazar-Marioni SMarnat GHenninger NKyheng MChervak LMTan BYTer Schiphorst AGuenego AAmllay AGonzalez NRTancredi IKuhn ALBellante FOta TJesser JDyzmann CGory BDmytriw AAValente ILubicz BColasurdo MAbdalkader MHeit JJJabbour PAziz YKhandelwal PSiegler JERadu RACancelliere NMSheth SClarencon FPedro Filipe JPatel ABRenieri LNguyen TNBerge JYeo LLNedelcu STjoumakaris SIKlein PGhozy SForestier GKan PTDiestro JDBThomas AJMarotta TRStapleton CJDusart AEl Naamani KHecker CSaleme SFiehler JAlexandre AMRouchaud AElhorany MfalseFirst pass effect as an independent predictor of functional outcomes in medium vessel occlusions: An analysis of an international multicenter study.<h4>Introduction</h4>First pass effect (FPE), achievement of complete recanalization (mTICI 2c/3) with a single pass, is a significant predictor of favorable outcomes for endovascular treatment (EVT) in large vessel occlusion stroke (LVO). However, data concerning the impact on functional outcomes and predictors of FPE in medium vessel occlusions (MeVO) are scarce.<h4>Patients and methods</h4>We conducted an international retrospective study on MeVO cases. Multivariable logistic modeling was used to establish independent predictors of FPE. Clinical and safety outcomes were compared between the two study groups (FPE vs non-FPE) using logistic regression models. Good outcome was defined as modified Rankin Scale 0-2 at 3 months.<h4>Results</h4>Eight hundred thirty-six patients with a final mT2024-01-01T00:00:00Z2024 Mar2026-06-15T06:36:46.538Z2024-11-09T19:16:31.417ZS-EPMC109168153788524310.1177/23969873231208276