{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang L"],"funding":["NIAID NIH HHS","NIGMS NIH HHS"],"pagination":["ar38"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10916879"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(3)"],"pubmed_abstract":["The ubiquitination of transmembrane receptors regulates endocytosis, intracellular traffic, and signal transduction. Bone marrow-derived macrophages from myeloid Cbl<sup>-/-</sup> and Cbl-b<sup>-/-</sup> double knockout (DKO) mice display sustained proliferation mirroring the myeloproliferative disease that these mice succumb to. Here, we found that the ubiquitin ligases Cbl and Cbl-b have overlapping functions for controlling the endocytosis and intracellular traffic of the CSF-1R. DKO macrophages displayed complete loss of ubiquitination of the CSF-1R whereas partial ubiquitination was observed for either single Cbl<sup>-/-</sup> or Cbl-b<sup>-/-</sup> macrophages. Unlike wild type, DKO macrophages were immortal and displayed slower CSF-1R internalization, elevated AKT signaling, and a f"],"journal":["Molecular biology of the cell"],"pubmed_title":["The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes."],"pmcid":["PMC10916879"],"funding_grant_id":["P20 GM135008","U01 AI148153"],"pubmed_authors":["Low-Nam ST","Band H","Ahmad G","Hoppe AD","Huang L","An W","Thiex NW","Lou J","Kerkvliet JG"],"additional_accession":[]},"is_claimable":false,"name":"The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes.","description":"The ubiquitination of transmembrane receptors regulates endocytosis, intracellular traffic, and signal transduction. Bone marrow-derived macrophages from myeloid Cbl<sup>-/-</sup> and Cbl-b<sup>-/-</sup> double knockout (DKO) mice display sustained proliferation mirroring the myeloproliferative disease that these mice succumb to. Here, we found that the ubiquitin ligases Cbl and Cbl-b have overlapping functions for controlling the endocytosis and intracellular traffic of the CSF-1R. DKO macrophages displayed complete loss of ubiquitination of the CSF-1R whereas partial ubiquitination was observed for either single Cbl<sup>-/-</sup> or Cbl-b<sup>-/-</sup> macrophages. Unlike wild type, DKO macrophages were immortal and displayed slower CSF-1R internalization, elevated AKT signaling, and a f","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-02T10:26:29.512Z","creation":"2025-04-06T00:49:00.322Z"},"accession":"S-EPMC10916879","cross_references":{"pubmed":["38170572"],"doi":["10.1091/mbc.E23-09-0345"]}}