{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hou Y"],"funding":["NIA NIH HHS","NCI NIH HHS","NINDS NIH HHS","NIGMS NIH HHS"],"pagination":["1334-1349"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10916937"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(2)"],"pubmed_abstract":["<h4>Introduction</h4>The molecular mechanisms that contribute to sex differences, in particular female predominance, in Alzheimer's disease (AD) prevalence, symptomology, and pathology, are incompletely understood.<h4>Methods</h4>To address this problem, we investigated cellular metabolism and immune responses (\"immunometabolism endophenotype\") across AD individuals as a function of sex with diverse clinical diagnosis of cognitive status at death (cogdx), Braak staging, and Consortium to Establish a Registry for AD (CERAD) scores using human cortex metabolomics and transcriptomics data from the Religious Orders Study / Memory and Aging Project (ROSMAP) cohort.<h4>Results</h4>We identified sex-specific metabolites, immune and metabolic genes, and pathways associated with the AD diagnosis an"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Microglial immunometabolism endophenotypes contribute to sex difference in Alzheimer's disease."],"pmcid":["PMC10916937"],"funding_grant_id":["R01 AG082118","R01 AG015819","U01 AG061356","R01 AG074392","R01 AG036836","R01 AG066707","U01 NS093334","R01 AG053798","P20 AG068053","U01 AG073323","R01 AG069901","U01 AG046152","P01 CA245705","R35 AG071476","P30 AG072959","P20 GM109025","R01 AG030146","RF1 NS133812","R01 AG076448","P30 AG010161","R56 AG074001","R01 AG084250","R21 AG083003","U19 AG063744","U01 AG032984","K08 AG065463","RF1 AG082211","R01 AG017917"],"pubmed_authors":["Cheng F","Caldwell JZK","Leverenz JB","Pieper AA","Lathia JD","Hou Y","Cummings J"],"additional_accession":[]},"is_claimable":false,"name":"Microglial immunometabolism endophenotypes contribute to sex difference in Alzheimer's disease.","description":"<h4>Introduction</h4>The molecular mechanisms that contribute to sex differences, in particular female predominance, in Alzheimer's disease (AD) prevalence, symptomology, and pathology, are incompletely understood.<h4>Methods</h4>To address this problem, we investigated cellular metabolism and immune responses (\"immunometabolism endophenotype\") across AD individuals as a function of sex with diverse clinical diagnosis of cognitive status at death (cogdx), Braak staging, and Consortium to Establish a Registry for AD (CERAD) scores using human cortex metabolomics and transcriptomics data from the Religious Orders Study / Memory and Aging Project (ROSMAP) cohort.<h4>Results</h4>We identified sex-specific metabolites, immune and metabolic genes, and pathways associated with the AD diagnosis an","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-07-15T13:51:34.393Z","creation":"2026-07-05T03:11:27.74Z"},"accession":"S-EPMC10916937","cross_references":{"pubmed":["37985399"],"doi":["10.1002/alz.13546"]}}