biostudies-literatureHou YNIA NIH HHSNCI NIH HHSNINDS NIH HHSNIGMS NIH HHS1334-1349https://www.ebi.ac.uk/biostudies/studies/S-EPMC10916937biostudies-literatureUnknown20(2)<h4>Introduction</h4>The molecular mechanisms that contribute to sex differences, in particular female predominance, in Alzheimer's disease (AD) prevalence, symptomology, and pathology, are incompletely understood.<h4>Methods</h4>To address this problem, we investigated cellular metabolism and immune responses ("immunometabolism endophenotype") across AD individuals as a function of sex with diverse clinical diagnosis of cognitive status at death (cogdx), Braak staging, and Consortium to Establish a Registry for AD (CERAD) scores using human cortex metabolomics and transcriptomics data from the Religious Orders Study / Memory and Aging Project (ROSMAP) cohort.<h4>Results</h4>We identified sex-specific metabolites, immune and metabolic genes, and pathways associated with the AD diagnosis anAlzheimer's & dementia : the journal of the Alzheimer's AssociationMicroglial immunometabolism endophenotypes contribute to sex difference in Alzheimer's disease.PMC10916937R01 AG082118R01 AG015819U01 AG061356R01 AG074392R01 AG036836R01 AG066707U01 NS093334R01 AG053798P20 AG068053U01 AG073323R01 AG069901U01 AG046152P01 CA245705R35 AG071476P30 AG072959P20 GM109025R01 AG030146RF1 NS133812R01 AG076448P30 AG010161R56 AG074001R01 AG084250R21 AG083003U19 AG063744U01 AG032984K08 AG065463RF1 AG082211R01 AG017917Cheng FCaldwell JZKLeverenz JBPieper AALathia JDHou YCummings JfalseMicroglial immunometabolism endophenotypes contribute to sex difference in Alzheimer's disease.<h4>Introduction</h4>The molecular mechanisms that contribute to sex differences, in particular female predominance, in Alzheimer's disease (AD) prevalence, symptomology, and pathology, are incompletely understood.<h4>Methods</h4>To address this problem, we investigated cellular metabolism and immune responses ("immunometabolism endophenotype") across AD individuals as a function of sex with diverse clinical diagnosis of cognitive status at death (cogdx), Braak staging, and Consortium to Establish a Registry for AD (CERAD) scores using human cortex metabolomics and transcriptomics data from the Religious Orders Study / Memory and Aging Project (ROSMAP) cohort.<h4>Results</h4>We identified sex-specific metabolites, immune and metabolic genes, and pathways associated with the AD diagnosis an2024-01-01T00:00:00Z2024 Feb2026-07-15T13:51:34.393Z2026-07-05T03:11:27.74ZS-EPMC109169373798539910.1002/alz.13546