biostudies-literatureBaker LDNIA NIH HHSAlzheimer&apos;s AssociationAlzheimer's Association769-782https://www.ebi.ac.uk/biostudies/studies/S-EPMC10916955biostudies-literatureUnknown20(2)<h4>Introduction</h4>The U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER) is conducted to confirm and expand the results of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) in Americans.<h4>Methods</h4>U.S. POINTER was planned as a 2-year randomized controlled trial of two lifestyle interventions in 2000 older adults at risk for dementia due to well-established factors. The primary outcome is a global cognition composite that permits harmonization with FINGER.<h4>Results</h4>U.S. POINTER is centrally coordinated and conducted at five clinical sites (ClinicalTrials.gov: NCT03688126). Outcomes assessments are completed at baseline and every 6 months. Both interventions focus on exercise, diet, cognAlzheimer's & dementia : the journal of the Alzheimer's AssociationStudy design and methods: U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER).PMC1091695519-61154119‐611541P30 AG072947Tangney CCWoolard NSalloway SAntkowiak SVentrelle JAlexander ASMorris MCEspeland MANgandu TPapp KVCleveland MLDay CEWilmoth SMcDonald AMMatongo OPavlik VNKatula JCarrillo MCSolomon AYu MMHill MAGraef SLovato LFelton DReynolds TWhitmer RAWilliams BJRushing SKivipelto MElbein RRaman RGhadimi Nouran MU.S. POINTER Study GroupSpell JLambert KLSnyder HMWilliamson JDBaker LDTomaszewski Farias SGitelman DRWing RRfalseStudy design and methods: U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER).<h4>Introduction</h4>The U.S. study to protect brain health through lifestyle intervention to reduce risk (U.S. POINTER) is conducted to confirm and expand the results of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) in Americans.<h4>Methods</h4>U.S. POINTER was planned as a 2-year randomized controlled trial of two lifestyle interventions in 2000 older adults at risk for dementia due to well-established factors. The primary outcome is a global cognition composite that permits harmonization with FINGER.<h4>Results</h4>U.S. POINTER is centrally coordinated and conducted at five clinical sites (ClinicalTrials.gov: NCT03688126). Outcomes assessments are completed at baseline and every 6 months. Both interventions focus on exercise, diet, cogn2024-01-01T00:00:00Z2024 Feb2026-07-15T12:01:56.514Z2026-07-04T03:12:33.801ZS-EPMC109169553777621010.1002/alz.13365