{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Scoyni F"],"funding":["Academy of Finland","Antti and Tyyne Soininen Foundation","Instrumentariumin Tiedesäätiö","Instrumentarium Science Foundation","Framework Programme of the European Union Marie Skłodowska Curie","The Finnish Cultural Foundation","Sigrid Juselius Foundation","Kuopio University Foundation","Saastamoinen Foundation","Inkeri and Mauri Vänskä Foundation"],"pagination":["954-974"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10916983"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(2)"],"pubmed_abstract":["<h4>Introduction</h4>Alzheimer's disease (AD) is a neurodegenerative disease and the main cause of dementia in the elderly. AD pathology is characterized by accumulation of microglia around the beta-amyloid (Aβ) plaques which assumes disease-specific transcriptional signatures, as for the disease-associated microglia (DAM). However, the regulators of microglial phagocytosis are still unknown.<h4>Methods</h4>We isolated Aβ-laden microglia from the brain of 5xFAD mice for RNA sequencing to characterize the transcriptional signature in phagocytic microglia and to identify the key non-coding RNAs capable of regulating microglial phagocytosis. Through spatial sequencing, we show the transcriptional changes of microglia in the AD mouse brain in relation to Aβ proximity.<h4>Results</h4>Finally, we show that phagocytic messenger RNAs are regulated by miR-7a-5p, miR-29a-3p and miR-146a-5p microRNAs and segregate the DAM population into phagocytic and non-phagocytic states.<h4>Discussion</h4>Our study pinpoints key regulators of microglial Aβ clearing capacity suggesting new targets for future therapeutic approaches."],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs."],"pmcid":["PMC10916983"],"funding_grant_id":["740264","298071","307309","328287"],"pubmed_authors":["Grubman A","Yla-Herttuala S","Valimaki NN","Malm T","Scoyni F","Giudice L","Vaananen MA","Downes N","Turunen TA","Choo XY","Korhonen P","de Vries HE","Kaikkonen MU","Makinen P","Hansen TB","Rozemuller AJ","Polo J","Korvenlaita N"],"additional_accession":[]},"is_claimable":false,"name":"Alzheimer's disease-induced phagocytic microglia express a specific profile of coding and non-coding RNAs.","description":"<h4>Introduction</h4>Alzheimer's disease (AD) is a neurodegenerative disease and the main cause of dementia in the elderly. AD pathology is characterized by accumulation of microglia around the beta-amyloid (Aβ) plaques which assumes disease-specific transcriptional signatures, as for the disease-associated microglia (DAM). However, the regulators of microglial phagocytosis are still unknown.<h4>Methods</h4>We isolated Aβ-laden microglia from the brain of 5xFAD mice for RNA sequencing to characterize the transcriptional signature in phagocytic microglia and to identify the key non-coding RNAs capable of regulating microglial phagocytosis. Through spatial sequencing, we show the transcriptional changes of microglia in the AD mouse brain in relation to Aβ proximity.<h4>Results</h4>Finally, we show that phagocytic messenger RNAs are regulated by miR-7a-5p, miR-29a-3p and miR-146a-5p microRNAs and segregate the DAM population into phagocytic and non-phagocytic states.<h4>Discussion</h4>Our study pinpoints key regulators of microglial Aβ clearing capacity suggesting new targets for future therapeutic approaches.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-07-05T03:14:21.675Z","creation":"2026-07-05T03:12:10.189Z"},"accession":"S-EPMC10916983","cross_references":{"pubmed":["37828821"],"doi":["10.1002/alz.13502"]}}