biostudies-literatureAaronson ANIA NIH HHSNIMH NIH HHSNINDS NIH HHSNational Institutes of HealthAlzheimer&apos;s AssociationAlzheimer's AssociationNIH HHS846-857https://www.ebi.ac.uk/biostudies/studies/S-EPMC10916998biostudies-literatureUnknown20(2)<h4>Background</h4>In Alzheimer's disease (AD) research, subjective reports of cognitive and functional decline from participant-study partner dyads is an efficient method of assessing cognitive impairment and clinical progression.<h4>Methods</h4>Demographics and subjective cognitive/functional decline (Everyday Cognition Scale [ECog]) scores from dyads enrolled in the Brain Health Registry (BHR) Study Partner Portal were analyzed. Associations between dyad characteristics and both ECog scores and study engagement were investigated.<h4>Results</h4>A total of 10,494 BHR participants (mean age = 66.9 ± 12.16 standard deviations, 67.4% female) have enrolled study partners (mean age = 64.3 ± 14.3 standard deviations, 49.3% female), including 8987 dyads with a participant 55 years of age or older. Older and more educated study partners were more likely to complete tasks and return for follow-up. Twenty-five percent to 27% of older adult participants had self and study partner-report ECog scores indicating a possible cognitive impairment.<h4>Discussion</h4>The BHR Study Partner Portal is a unique digital tool for capturing dyadic data, with high impact applications in the clinical neuroscience and AD fields. Highlights The Brain Health Registry (BHR) Study Partner Portal is a novel, digital platform of >10,000 dyads. Collection of dyadic online subjective cognitive and functional data is feasible. The portal has good usability as evidenced by positive study partner feedback. The portal is a potential scalable strategy for cognitive impairment screening in older adults.Alzheimer's & dementia : the journal of the Alzheimer's AssociationBrain Health Registry Study Partner Portal: Novel infrastructure for digital, dyadic data collection.PMC10916998BHR-16-459161R33AG062867R21 NS120629U2C AG060426K01 AG054762K01AG055692R33 AG062867K01 AG055692U01 AG057195U24 AG057437U19 AG024904P30 AG062422R01 MH117114R01 AG053798RF1 AG059009R35 AG072362F32AG072730-01RF1 MH125928F32AG072730‐01R01 NS119651R01 AG063954BHR‐16‐459161R01 MH101472F32 AG072730Mackin RSAshford MTUlbricht ATurner RWDecker JTruran DAaronson AFockler JCamacho MRRabinovici GDeNicola AConti CWeiner MWJin CGrill JDNosheny RLTank RFlenniken DBride JCarrillo MCfalseBrain Health Registry Study Partner Portal: Novel infrastructure for digital, dyadic data collection.<h4>Background</h4>In Alzheimer's disease (AD) research, subjective reports of cognitive and functional decline from participant-study partner dyads is an efficient method of assessing cognitive impairment and clinical progression.<h4>Methods</h4>Demographics and subjective cognitive/functional decline (Everyday Cognition Scale [ECog]) scores from dyads enrolled in the Brain Health Registry (BHR) Study Partner Portal were analyzed. Associations between dyad characteristics and both ECog scores and study engagement were investigated.<h4>Results</h4>A total of 10,494 BHR participants (mean age = 66.9 ± 12.16 standard deviations, 67.4% female) have enrolled study partners (mean age = 64.3 ± 14.3 standard deviations, 49.3% female), including 8987 dyads with a participant 55 years of age or older. Older and more educated study partners were more likely to complete tasks and return for follow-up. Twenty-five percent to 27% of older adult participants had self and study partner-report ECog scores indicating a possible cognitive impairment.<h4>Discussion</h4>The BHR Study Partner Portal is a unique digital tool for capturing dyadic data, with high impact applications in the clinical neuroscience and AD fields. Highlights The Brain Health Registry (BHR) Study Partner Portal is a novel, digital platform of >10,000 dyads. Collection of dyadic online subjective cognitive and functional data is feasible. The portal has good usability as evidenced by positive study partner feedback. The portal is a potential scalable strategy for cognitive impairment screening in older adults.2024-01-01T00:00:00Z2024 Feb2026-04-18T11:15:48.349Z2026-04-07T14:34:24.05ZS-EPMC109169983779720510.1002/alz.13492