{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alber J"],"funding":["NIA NIH HHS","Alzheimer Nederland","Medical Research Council","Warren Alpert Foundation"],"pagination":["728-740"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10917008"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["There is emerging evidence that amyloid beta protein (Aβ) and tau-related lesions in the retina are associated with Alzheimer's disease (AD). Aβ and hyperphosphorylated (p)-tau deposits have been described in the retina and were associated with small amyloid spots visualized by in vivo imaging techniques as well as degeneration of the retina. These changes correlate with brain amyloid deposition as determined by histological quantification, positron emission tomography (PET) or clinical diagnosis of AD. However, the literature is not coherent on these histopathological and in vivo imaging findings. One important reason for this is the variability in the methods and the interpretation of findings across different studies. In this perspective, we indicate the critical methodological deviatio"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions."],"pmcid":["PMC10917008"],"funding_grant_id":["R01 AG055865","RF1 AG073979","R01 AG079241","U24 AG057437","U19 AG078109","R01 AG075998","R21 AG074153","R01 AG058533","R01 AG018440","R37 AG018440","P30 AG062429","R01 AG056478","WE.03‐2021‐14","MR/N029941/1","R01 AG073979","P30 AG066530","R56 AG058533","R01 AG058252"],"pubmed_authors":["Koronyo-Hamaoui M","Thal DR","De Groef L","Lengyel I","den Haan J","Rissman RA","Alber J","Alzheimer's Association ISTAART “The Eye as a Biomarker for AD” Professional Interest Area","Bouwman F"],"additional_accession":[]},"is_claimable":false,"name":"Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions.","description":"There is emerging evidence that amyloid beta protein (Aβ) and tau-related lesions in the retina are associated with Alzheimer's disease (AD). Aβ and hyperphosphorylated (p)-tau deposits have been described in the retina and were associated with small amyloid spots visualized by in vivo imaging techniques as well as degeneration of the retina. These changes correlate with brain amyloid deposition as determined by histological quantification, positron emission tomography (PET) or clinical diagnosis of AD. However, the literature is not coherent on these histopathological and in vivo imaging findings. One important reason for this is the variability in the methods and the interpretation of findings across different studies. In this perspective, we indicate the critical methodological deviatio","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jan","modification":"2026-07-15T00:41:52.022Z","creation":"2026-06-27T03:06:12.415Z"},"accession":"S-EPMC10917008","cross_references":{"pubmed":["37917365"],"doi":["10.1002/alz.13529"]}}