{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(2)"],"submitter":["Slee MG"],"funding":["Australian Alzheimer&apos;s Research Foundation","Alzheimer&apos;s Drug Discovery Foundation","Dementia Collaborative Research Centres, Australia","Yulgilbar Foundation","National Health and Medical Research Council","Alzheimer&apos;s Association","Science and Industry Endowment Fund","Alzheimer's Association"],"pubmed_abstract":["<h4>Introduction</h4>The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (Aβ) over 15 years in a cohort of cognitively unimpaired older adults.<h4>Methods</h4>PA and Aβ measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain Aβ. Moderation analyses examined apolipoprotein E (APOE) ε4 carriage impact on the PA-Aβ relationship.<h4>Results</h4>PA was not associated with brain Aβ at baseline (β = -0.001, p = 0.72) or over time (β = -0.26, p = 0.24). APOE ε4 status did not moderate the PA-Aβ relationship over time (β = 0.12, p = 0.73). Brain Aβ levels did not predict PA trajectory (β = -54.26, p = 0.59).<h4>Discussion</h4>Our study did not identify a relationship between habitual PA and brain Aβ levels.<h4>Highlights</h4>Physical activity levels did not predict brain amyloid beta (Aβ) levels over time in cognitively unimpaired older adults (≥60 years of age). Apolipoprotein E (APOE) ε4 carrier status did not moderate the physical activity-brain Aβ relationship over time. Physical activity trajectories were not impacted by brain Aβ levels."],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pagination":["1350-1359"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10917015"],"repository":["biostudies-literature"],"pubmed_title":["Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults."],"pmcid":["PMC10917015"],"pubmed_authors":["Ames D","Rainey-Smith SR","Maruff P","Taddei K","Laws SM","Brown BM","Martins RN","Villemagne VL","Masters CL","Slee MG","Dore V","Doecke JD","Rowe CC","Erickson KI","Sohrabi HR"],"additional_accession":[]},"is_claimable":false,"name":"Physical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults.","description":"<h4>Introduction</h4>The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (Aβ) over 15 years in a cohort of cognitively unimpaired older adults.<h4>Methods</h4>PA and Aβ measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain Aβ. Moderation analyses examined apolipoprotein E (APOE) ε4 carriage impact on the PA-Aβ relationship.<h4>Results</h4>PA was not associated with brain Aβ at baseline (β = -0.001, p = 0.72) or over time (β = -0.26, p = 0.24). APOE ε4 status did not moderate the PA-Aβ relationship over time (β = 0.12, p = 0.73). Brain Aβ levels did not predict PA trajectory (β = -54.26, p = 0.59).<h4>Discussion</h4>Our study did not identify a relationship between habitual PA and brain Aβ levels.<h4>Highlights</h4>Physical activity levels did not predict brain amyloid beta (Aβ) levels over time in cognitively unimpaired older adults (≥60 years of age). Apolipoprotein E (APOE) ε4 carrier status did not moderate the physical activity-brain Aβ relationship over time. Physical activity trajectories were not impacted by brain Aβ levels.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-06-24T03:09:04.931Z","creation":"2026-06-24T03:06:11.066Z"},"accession":"S-EPMC10917015","cross_references":{"pubmed":["37984813"],"doi":["10.1002/alz.13556"]}}