biostudies-literatureUnknown20(2)Slee MGAustralian Alzheimer&apos;s Research FoundationAlzheimer&apos;s Drug Discovery FoundationDementia Collaborative Research Centres, AustraliaYulgilbar FoundationNational Health and Medical Research CouncilAlzheimer&apos;s AssociationScience and Industry Endowment FundAlzheimer's Association<h4>Introduction</h4>The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (Aβ) over 15 years in a cohort of cognitively unimpaired older adults.<h4>Methods</h4>PA and Aβ measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain Aβ. Moderation analyses examined apolipoprotein E (APOE) ε4 carriage impact on the PA-Aβ relationship.<h4>Results</h4>PA was not associated with brain Aβ at baseline (β = -0.001, p = 0.72) or over time (β = -0.26, p = 0.24). APOE ε4 status did not moderate the PA-Aβ relationship over time (β = 0.12, p = 0.73). Brain Aβ levels did not predict PA trajectory (β = -54.26, p = 0.59).<h4>Discussion</h4>Our study did not identify a relationship between habitual PA and brain Aβ levels.<h4>Highlights</h4>Physical activity levels did not predict brain amyloid beta (Aβ) levels over time in cognitively unimpaired older adults (≥60 years of age). Apolipoprotein E (APOE) ε4 carrier status did not moderate the physical activity-brain Aβ relationship over time. Physical activity trajectories were not impacted by brain Aβ levels.Alzheimer's & dementia : the journal of the Alzheimer's Association1350-1359https://www.ebi.ac.uk/biostudies/studies/S-EPMC10917015biostudies-literaturePhysical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults.PMC10917015Ames DRainey-Smith SRMaruff PTaddei KLaws SMBrown BMMartins RNVillemagne VLMasters CLSlee MGDore VDoecke JDRowe CCErickson KISohrabi HRfalsePhysical activity and brain amyloid beta: A longitudinal analysis of cognitively unimpaired older adults.<h4>Introduction</h4>The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (Aβ) over 15 years in a cohort of cognitively unimpaired older adults.<h4>Methods</h4>PA and Aβ measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging. Regression modeling examined cross-sectional and longitudinal relationships between PA and brain Aβ. Moderation analyses examined apolipoprotein E (APOE) ε4 carriage impact on the PA-Aβ relationship.<h4>Results</h4>PA was not associated with brain Aβ at baseline (β = -0.001, p = 0.72) or over time (β = -0.26, p = 0.24). APOE ε4 status did not moderate the PA-Aβ relationship over time (β = 0.12, p = 0.73). Brain Aβ levels did not predict PA trajectory (β = -54.26, p = 0.59).<h4>Discussion</h4>Our study did not identify a relationship between habitual PA and brain Aβ levels.<h4>Highlights</h4>Physical activity levels did not predict brain amyloid beta (Aβ) levels over time in cognitively unimpaired older adults (≥60 years of age). Apolipoprotein E (APOE) ε4 carrier status did not moderate the physical activity-brain Aβ relationship over time. Physical activity trajectories were not impacted by brain Aβ levels.2024-01-01T00:00:00Z2024 Feb2026-06-24T03:09:04.931Z2026-06-24T03:06:11.066ZS-EPMC109170153798481310.1002/alz.13556