biostudies-literatureSong YNCI NIH HHSNational Institutes of HealthNIH HHS1076-1088https://www.ebi.ac.uk/biostudies/studies/S-EPMC10917042biostudies-literatureUnknown20(2)<h4>Introduction</h4>Evidence is limited on the role of mid-life Dietary Approaches to Stop Hypertension (DASH) diet in late-life subjective cognitive complaints (SCCs).<h4>Methods</h4>We included 5116 women (mean age in 1985-1991: 46 years) from the New York University Women's Health Study. SCCs were assessed from 2018 to 2020 (mean age: 79 years) by a 6-item questionnaire.<h4>Results</h4>Compared to women in the bottom quartile of the DASH scores, the odds ratio (OR) for having two or more SCCs was 0.83 (95% confidence interval: 0.70-0.99) for women in the top quartile of DASH scores at baseline (P for trend = 0.019). The association was similar with multiple imputation and inverse probability weighting to account for potential selection bias. The inverse association was stronger in women without a history of cancer (P for interaction = 0.003).<h4>Discussion</h4>Greater adherence to the DASH diet in mid-life was associated with lower prevalence of late-life SCCs in women.Alzheimer's & dementia : the journal of the Alzheimer's AssociationMid-life adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and late-life subjective cognitive complaints in women.PMC10917042U01 CA182934India-Aldana SAfanasyeva YClendenen TVSharma SGu YKoenig KLChen YZeleniuch-Jacquotte AWu FSong YfalseMid-life adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and late-life subjective cognitive complaints in women.<h4>Introduction</h4>Evidence is limited on the role of mid-life Dietary Approaches to Stop Hypertension (DASH) diet in late-life subjective cognitive complaints (SCCs).<h4>Methods</h4>We included 5116 women (mean age in 1985-1991: 46 years) from the New York University Women's Health Study. SCCs were assessed from 2018 to 2020 (mean age: 79 years) by a 6-item questionnaire.<h4>Results</h4>Compared to women in the bottom quartile of the DASH scores, the odds ratio (OR) for having two or more SCCs was 0.83 (95% confidence interval: 0.70-0.99) for women in the top quartile of DASH scores at baseline (P for trend = 0.019). The association was similar with multiple imputation and inverse probability weighting to account for potential selection bias. The inverse association was stronger in women without a history of cancer (P for interaction = 0.003).<h4>Discussion</h4>Greater adherence to the DASH diet in mid-life was associated with lower prevalence of late-life SCCs in women.2024-01-01T00:00:00Z2024 Feb2025-08-12T03:04:35.641Z2025-08-12T03:04:35.641ZS-EPMC109170423786108010.1002/alz.13468