{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Duchowny KA"],"funding":["NCATS NIH HHS","NIA NIH HHS"],"pagination":["eadj6411"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10917337"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(10)"],"pubmed_abstract":["Social stress experienced in childhood is associated with adverse health later in life. Mitochondrial function has been implicated as a mechanism for how stressful life events \"get under the skin\" to influence physical well-being. Using data from the Study of Muscle, Mobility, and Aging (<i>n</i> = 879, 59% women), linear models examined whether adverse childhood events (i.e., physical abuse) were associated with two measures of skeletal muscle mitochondrial energetics in older adults: (i) maximal adenosine triphosphate production (ATP<sub>max</sub>) and (ii) maximal state 3 respiration (Max OXPHOS). Forty-five percent of the sample reported experiencing one or more adverse childhood events. After adjustment, each additional event was associated with -0.08 SD (95% confidence interval = -0.13, -0.02) lower ATP<sub>max</sub>. No association was observed with Max OXPHOS. Adverse childhood events are associated with lower ATP production in later life. Findings indicate that mitochondrial function may be a mechanism for understanding how early social stress influences health in later life."],"journal":["Science advances"],"pubmed_title":["Childhood adverse life events and skeletal muscle mitochondrial function."],"pmcid":["PMC10917337"],"funding_grant_id":["P30 AG021332","R01 AG059416","R00 AG066846","UL1 TR001420","R56 AG059416","P30 AG024827"],"pubmed_authors":["Molina AJA","Hepple RT","Kramer PA","Kritchevsky SB","Coen PM","Duchowny KA","Cummings SR","Diaz-Ramierz LG","Toledo FGS","Newman AB","Marcinek DJ","Lui LY","Cawthon PM","Mau T"],"additional_accession":[]},"is_claimable":false,"name":"Childhood adverse life events and skeletal muscle mitochondrial function.","description":"Social stress experienced in childhood is associated with adverse health later in life. Mitochondrial function has been implicated as a mechanism for how stressful life events \"get under the skin\" to influence physical well-being. Using data from the Study of Muscle, Mobility, and Aging (<i>n</i> = 879, 59% women), linear models examined whether adverse childhood events (i.e., physical abuse) were associated with two measures of skeletal muscle mitochondrial energetics in older adults: (i) maximal adenosine triphosphate production (ATP<sub>max</sub>) and (ii) maximal state 3 respiration (Max OXPHOS). Forty-five percent of the sample reported experiencing one or more adverse childhood events. After adjustment, each additional event was associated with -0.08 SD (95% confidence interval = -0.13, -0.02) lower ATP<sub>max</sub>. No association was observed with Max OXPHOS. Adverse childhood events are associated with lower ATP production in later life. Findings indicate that mitochondrial function may be a mechanism for understanding how early social stress influences health in later life.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-19T10:00:16.892Z","creation":"2025-04-19T10:00:16.892Z"},"accession":"S-EPMC10917337","cross_references":{"pubmed":["38446898"],"doi":["10.1126/sciadv.adj6411"]}}