{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(4)"],"submitter":["de Souza Lopes L"],"pubmed_abstract":["A drug that is widely used in the treatment of psychiatric disorder is lithium (Li) salts. The people who make therapeutic use of this drug develop a series of side effects. Through metataxonomic data, this study assessed the impacts of lithium, as Li carbonate or Li-enriched mushrooms, on the microbial composition of the ileum, colon, and feces of piglets. Employing Bray-Curtis metric, no differences were observed among the treatments evaluated. Nevertheless, the alpha diversity indices showed differences in the Simpson, Shannon, and Chao-1 indices in the colon and Chao-1 in the feces in the diets with Li compared with the diets without Li. The taxa with the highest relative abundance varied among the ileum, colon, and feces, with a predominance of the phyla Firmicutes, Bacteroidota, and Proteobacteria in diets with Li. Many groups of microorganisms that are important for the health of the host (e.g., <i>Lactobacillus</i>, Ruminococcaceae, <i>Enterorhabdus</i>, Muribaculaceae, and <i>Coprococcus</i>) had their relative abundance increased in animals that received diets with the recommended dose of lithium. Furthermore, there was an increase in the abundance of <i>Prevotellaceae</i> and <i>Bacteroidales</i> (in the diet with Li-enriched mushroom) and <i>Clostridia</i>, <i>Ruminococcus, Burkholderia,</i> and <i>Bacteroidales</i> (diets with Li carbonate) at the recommended dosages. This is the first study to show the effects of Li carbonate and Li-enriched mushrooms on the intestinal microbiota of piglets. Thus, the effects of lithium on the body may be related to its ability to change the composition of the intestinal microbiota.<h4>Supplementary information</h4>The online version contains supplementary material available at 10.1007/s13205-024-03938-3."],"journal":["3 Biotech"],"pagination":["102"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10917731"],"repository":["biostudies-literature"],"pubmed_title":["Intestinal microbial diversity of swines fed with different sources of lithium."],"pmcid":["PMC10917731"],"pubmed_authors":["Rocha GC","Kasuya MCM","de Souza Lopes L","da Silva JS","da Luz JMR","Lima HS","de Cassia Soares da Silva M","Mantovani HC"],"additional_accession":[]},"is_claimable":false,"name":"Intestinal microbial diversity of swines fed with different sources of lithium.","description":"A drug that is widely used in the treatment of psychiatric disorder is lithium (Li) salts. The people who make therapeutic use of this drug develop a series of side effects. Through metataxonomic data, this study assessed the impacts of lithium, as Li carbonate or Li-enriched mushrooms, on the microbial composition of the ileum, colon, and feces of piglets. Employing Bray-Curtis metric, no differences were observed among the treatments evaluated. Nevertheless, the alpha diversity indices showed differences in the Simpson, Shannon, and Chao-1 indices in the colon and Chao-1 in the feces in the diets with Li compared with the diets without Li. The taxa with the highest relative abundance varied among the ileum, colon, and feces, with a predominance of the phyla Firmicutes, Bacteroidota, and Proteobacteria in diets with Li. Many groups of microorganisms that are important for the health of the host (e.g., <i>Lactobacillus</i>, Ruminococcaceae, <i>Enterorhabdus</i>, Muribaculaceae, and <i>Coprococcus</i>) had their relative abundance increased in animals that received diets with the recommended dose of lithium. Furthermore, there was an increase in the abundance of <i>Prevotellaceae</i> and <i>Bacteroidales</i> (in the diet with Li-enriched mushroom) and <i>Clostridia</i>, <i>Ruminococcus, Burkholderia,</i> and <i>Bacteroidales</i> (diets with Li carbonate) at the recommended dosages. This is the first study to show the effects of Li carbonate and Li-enriched mushrooms on the intestinal microbiota of piglets. Thus, the effects of lithium on the body may be related to its ability to change the composition of the intestinal microbiota.<h4>Supplementary information</h4>The online version contains supplementary material available at 10.1007/s13205-024-03938-3.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-07-02T03:04:51.416Z","creation":"2025-07-02T03:04:51.416Z"},"accession":"S-EPMC10917731","cross_references":{"pubmed":["38464613"],"doi":["10.1007/s13205-024-03938-3"]}}