biostudies-literatureXu YSichuan Province Science and Technology Support ProgramNational Natural Science Foundation of ChinaSichuan UniversityNational Institutes of HealthNational Key Research and Development Program of China109298https://www.ebi.ac.uk/biostudies/studies/S-EPMC10918267biostudies-literatureUnknown27(3)Endometriosis is a chronic multisystem disease associated with immunological, genetic, hormonal, psychological, and neuroscientific factors, leading to a significant socioeconomic impact worldwide. Though multidisciplinary management is the ideal approach, there remains a scarcity of published interdisciplinary clinical trials at present. Here, we have conducted a comprehensive analysis of the characteristics and issues of interdisciplinary trials on endometriosis based on the clinical registration database ClinicalTrials.gov. Among all 387 endometriosis trials, 30% (116) were identified as interdisciplinary, mostly conducted in Europe and North America, and fully funded by non-industrial sources. We documented growth in both patient-centered multidisciplinary comprehensive management and iScienceAn overview and comprehensive analysis of interdisciplinary clinical research in endometriosis based on trial registry.PMC10918267KS021K19078177311982325039822732558182203422ZYZYTS00702022YFA110660081821002Zhou SDeng ZFei FXu YfalseAn overview and comprehensive analysis of interdisciplinary clinical research in endometriosis based on trial registry.Endometriosis is a chronic multisystem disease associated with immunological, genetic, hormonal, psychological, and neuroscientific factors, leading to a significant socioeconomic impact worldwide. Though multidisciplinary management is the ideal approach, there remains a scarcity of published interdisciplinary clinical trials at present. Here, we have conducted a comprehensive analysis of the characteristics and issues of interdisciplinary trials on endometriosis based on the clinical registration database ClinicalTrials.gov. Among all 387 endometriosis trials, 30% (116) were identified as interdisciplinary, mostly conducted in Europe and North America, and fully funded by non-industrial sources. We documented growth in both patient-centered multidisciplinary comprehensive management and 2024-01-01T00:00:00Z2024 Mar2026-05-29T10:04:51.508Z2025-04-07T02:13:15.514ZS-EPMC109182673845597310.1016/j.isci.2024.109298