{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Muller J"],"funding":["Swiss National Science Foundation"],"pagination":["2301001"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10918318"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["63(3)"],"pubmed_abstract":["Background
Our objective was to investigate the effect of a day-long exposure to high altitude on peak exercise capacity and safety in stable patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH).Methods
In a randomised controlled crossover trial, stable patients with PAH or distal CTEPH without resting hypoxaemia at low altitude performed two incremental exercise tests to exhaustion: one after 3-5 h at high altitude (2500 m) and one at low altitude (470 m).Results
In 27 patients with PAH/CTEPH (44% females, mean±sd age 62±14 years), maximal work rate was 110±64 W at 2500 m and 123±64 W at 470 m (-11%, 95% CI -16- -11%; p<0.001). Oxygen saturation measured by pulse oximetry and arterial oxygen tension at end-ex"],"journal":["The European respiratory journal"],"pubmed_title":["The effect of high altitude (2500 m) on incremental cycling exercise in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: a randomised controlled crossover trial."],"pmcid":["PMC10918318"],"funding_grant_id":["32003B_197706","197706"],"pubmed_authors":["Mayer L","Ulrich T","Ulrich S","Titz A","Furian M","Bloch KE","Schwarz EI","Bauer M","Forrer A","Luond L","Schneider SR","Lichtblau M","Muller J"],"additional_accession":[]},"is_claimable":false,"name":"The effect of high altitude (2500 m) on incremental cycling exercise in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: a randomised controlled crossover trial.","description":"Background
Our objective was to investigate the effect of a day-long exposure to high altitude on peak exercise capacity and safety in stable patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH).Methods
In a randomised controlled crossover trial, stable patients with PAH or distal CTEPH without resting hypoxaemia at low altitude performed two incremental exercise tests to exhaustion: one after 3-5 h at high altitude (2500 m) and one at low altitude (470 m).Results
In 27 patients with PAH/CTEPH (44% females, mean±sd age 62±14 years), maximal work rate was 110±64 W at 2500 m and 123±64 W at 470 m (-11%, 95% CI -16- -11%; p<0.001). Oxygen saturation measured by pulse oximetry and arterial oxygen tension at end-ex","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-15T10:24:07.496Z","creation":"2026-07-03T03:11:24.374Z"},"accession":"S-EPMC10918318","cross_references":{"pubmed":["38423623"],"doi":["10.1183/13993003.01001-2023"]}}