{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim SY"],"funding":["American Heart Association","BLRD VA","US Department of Veterans Affairs","NHLBI NIH HHS","National Institutes of Health","NIGMS NIH HHS","NIH HHS"],"pagination":["2127-2142"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10918510"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(29)"],"pubmed_abstract":["<b>Aim:</b> The impacts of synthetic high-density lipoprotein (sHDL) phospholipid components on anti-sepsis effects were investigated. <b>Methods:</b> sHDL composed with ApoA-I mimetic peptide (22A) and different phosphatidylcholines were prepared and characterized. Anti-inflammatory effects were investigated <i>in vitro</i> and <i>in vivo</i> on lipopolysaccharide (LPS)-induced inflammation models. <b>Results:</b> sHDLs composed with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (22A-DMPC) most effectively neutralizes LPS, inhibits toll-like receptor 4 recruitment into lipid rafts, suppresses nuclear factor κB signaling and promotes activating transcription factor 3 activating. The lethal endotoxemia animal model showed the protective effects of 22A-DMPC. <b>Conclusion:</b> Phospholipid components affect the stability and fluidity of nanodiscs, impacting the anti-septic efficacy of sHDLs. 22A-DMPC presents the strongest LPS binding and anti-inflammatory effects <i>in vitro</i> and <i>in vivo</i>, suggesting a potential sepsis treatment."],"journal":["Nanomedicine (London, England)"],"pubmed_title":["Phospholipids impact the protective effects of HDL-mimetic nanodiscs against lipopolysaccharide-induced inflammation."],"pmcid":["PMC10918510"],"funding_grant_id":["20POST3521818","R35 GM141478","VA I01BX004639","R01GM113832, R01GM121796, T32 GM007767, T32 GM008353, T32 HL125242","T32 GM008353","R01 GM113832","T32 HL125242","I01 BX004639","R01 GM121796","T32 GM007767","T32 GM145304"],"pubmed_authors":["Mei L","Olsen K","Kim SY","Yu M","Xia Z","Li XA","Schwendeman A","Fawaz MV","Morin EE","Kang J"],"additional_accession":[]},"is_claimable":false,"name":"Phospholipids impact the protective effects of HDL-mimetic nanodiscs against lipopolysaccharide-induced inflammation.","description":"<b>Aim:</b> The impacts of synthetic high-density lipoprotein (sHDL) phospholipid components on anti-sepsis effects were investigated. <b>Methods:</b> sHDL composed with ApoA-I mimetic peptide (22A) and different phosphatidylcholines were prepared and characterized. Anti-inflammatory effects were investigated <i>in vitro</i> and <i>in vivo</i> on lipopolysaccharide (LPS)-induced inflammation models. <b>Results:</b> sHDLs composed with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (22A-DMPC) most effectively neutralizes LPS, inhibits toll-like receptor 4 recruitment into lipid rafts, suppresses nuclear factor κB signaling and promotes activating transcription factor 3 activating. The lethal endotoxemia animal model showed the protective effects of 22A-DMPC. <b>Conclusion:</b> Phospholipid components affect the stability and fluidity of nanodiscs, impacting the anti-septic efficacy of sHDLs. 22A-DMPC presents the strongest LPS binding and anti-inflammatory effects <i>in vitro</i> and <i>in vivo</i>, suggesting a potential sepsis treatment.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Dec","modification":"2026-06-27T03:22:40.177Z","creation":"2025-04-07T04:19:40.75Z"},"accession":"S-EPMC10918510","cross_references":{"pubmed":["38197376"],"doi":["10.2217/nnm-2023-0222"]}}