{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Matos Simoes R"],"funding":["NCI NIH HHS","NIGMS NIH HHS"],"pagination":["754-773"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10918623"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(5)"],"pubmed_abstract":["Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC neoplasias and do not target specific oncogenic mutations in MM. Instead, these agents target pathways critical for PC biology yet largely dispensable for malignant or normal cells of most other lineages. Here we systematically characterized the lineage-preferential molecular dependencies of MM through genome-scale clustered regularly interspaced short palindromic repeats (CRISPR) studies in 19 MM versus hundreds of non-MM lines and identified 116 genes whose disruption more significantly affects MM cell fitness compared with other malignancies. These genes, some known, others not previously linked to MM, encode transcription factors,"],"journal":["Nature cancer"],"pubmed_title":["Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias."],"pmcid":["PMC10918623"],"funding_grant_id":["U01 CA176058","R01 CA196664","R01 CA180475","R01 CA276156","R01 CA192844","T32 GM007753","K22 CA266739","L30 CA231673","U01 CA225730","R01 CA050947","R01 CA179483"],"pubmed_authors":["Tsherniak A","Hu Y","Gupta VA","Ebert BL","Gandolfi S","Dashevsky O","Licht JD","Dupere-Richer D","Tang H","Mitsiades CS","Bradner JE","Keats JJ","Matthews GM","Hengeveld PJ","Dempster JM","Sievers QL","Dhimolea E","Aguirre AJ","Hahn WC","Downey-Kopyscinski SL","Ishiguro K","Barwick BG","Meyers RM","Glassner BJ","de Matos Simoes R","Sheffer M","Bryan JG","Culhane AC","Levy J","Gray NS","Bruggenthies JB","Kwiatkowski NP","Vazquez F","Shirasaki R","Auclair D","Groen RWJ","Dharia NV","McFarland JM","Ott CJ","Yamano S","Boise LH"],"additional_accession":[]},"is_claimable":false,"name":"Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias.","description":"Clinical progress in multiple myeloma (MM), an incurable plasma cell (PC) neoplasia, has been driven by therapies that have limited applications beyond MM/PC neoplasias and do not target specific oncogenic mutations in MM. Instead, these agents target pathways critical for PC biology yet largely dispensable for malignant or normal cells of most other lineages. Here we systematically characterized the lineage-preferential molecular dependencies of MM through genome-scale clustered regularly interspaced short palindromic repeats (CRISPR) studies in 19 MM versus hundreds of non-MM lines and identified 116 genes whose disruption more significantly affects MM cell fitness compared with other malignancies. These genes, some known, others not previously linked to MM, encode transcription factors,","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 May","modification":"2026-05-29T19:10:25.451Z","creation":"2026-04-08T05:43:35.103Z"},"accession":"S-EPMC10918623","cross_references":{"pubmed":["37237081"],"doi":["10.1038/s43018-023-00550-x"]}}