biostudies-literatureUnknown9(9)Salem MEA series of novel thieno[2,3-<i>b</i>]pyridines linked to <i>N</i>-aryl carboxamides or (carbonylphenoxy)-<i>N</i>-(aryl)acetamides, as well as bis(thieno[2,3-<i>b</i>]pyridines) linked to piperazine core via methanone or carbonylphenoxyethanone units, were synthesized by treating the appropriate chloroacetyl- or bis-bromoacetyl derivatives with 2-mercaptonicotinonitrile derivatives in ethanolic sodium ethoxide at reflux. The spectral data were used to determine the compositions of novel compounds.ACS omega10146-10159https://www.ebi.ac.uk/biostudies/studies/S-EPMC10918660biostudies-literatureUtility of 2-Chloro-<i>N</i>-arylacetamide and 1,1'-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines].PMC10918660Abdelhamid IASalem MEAbdullah AHZaki MEAElwahy AHMfalseUtility of 2-Chloro-<i>N</i>-arylacetamide and 1,1'-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines].A series of novel thieno[2,3-<i>b</i>]pyridines linked to <i>N</i>-aryl carboxamides or (carbonylphenoxy)-<i>N</i>-(aryl)acetamides, as well as bis(thieno[2,3-<i>b</i>]pyridines) linked to piperazine core via methanone or carbonylphenoxyethanone units, were synthesized by treating the appropriate chloroacetyl- or bis-bromoacetyl derivatives with 2-mercaptonicotinonitrile derivatives in ethanolic sodium ethoxide at reflux. The spectral data were used to determine the compositions of novel compounds.2024-01-01T00:00:00Z2024 Mar2025-04-04T12:58:28.189Z2025-04-04T12:58:28.189ZS-EPMC109186603846326010.1021/acsomega.3c06653