{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lathe R"],"funding":["NIA NIH HHS"],"pagination":["5209-5231"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10918877"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(11)"],"pubmed_abstract":["Microbial infections of the brain can lead to dementia, and for many decades microbial infections have been implicated in Alzheimer's disease (AD) pathology. However, a causal role for infection in AD remains contentious, and the lack of standardized detection methodologies has led to inconsistent detection/identification of microbes in AD brains. There is a need for a consensus methodology; the Alzheimer's Pathobiome Initiative aims to perform comparative molecular analyses of microbes in post mortem brains versus cerebrospinal fluid, blood, olfactory neuroepithelium, oral/nasopharyngeal tissue, bronchoalveolar, urinary, and gut/stool samples. Diverse extraction methodologies, polymerase chain reaction and sequencing techniques, and bioinformatic tools will be evaluated, in addition to di"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease: Research outline and call for collaboration."],"pmcid":["PMC10918877"],"funding_grant_id":["P30 AG066530","P30 AG062429"],"pubmed_authors":["Doty RL","Schultek NM","Ekberg J","Nara PL","Sacco G","St John J","Hammond C","Bell ND","Intracell Research Group Consortium Collaborators","Tanzi RE","Moein ST","Balin BJ","Auber LA","Corry DB","Rissman RA","Whittum-Hudson J","Hahn DL","Lathe R","Itzhaki R","Haas JG","Ehrlich GD","Perry G","Albensi BC","McLaughlin G","Imbimbo BP","Konig A","Eimer WA","Hudson AP","Breitschwerdt EB","Linz N","Nelson ML"],"additional_accession":[]},"is_claimable":false,"name":"Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease: Research outline and call for collaboration.","description":"Microbial infections of the brain can lead to dementia, and for many decades microbial infections have been implicated in Alzheimer's disease (AD) pathology. However, a causal role for infection in AD remains contentious, and the lack of standardized detection methodologies has led to inconsistent detection/identification of microbes in AD brains. There is a need for a consensus methodology; the Alzheimer's Pathobiome Initiative aims to perform comparative molecular analyses of microbes in post mortem brains versus cerebrospinal fluid, blood, olfactory neuroepithelium, oral/nasopharyngeal tissue, bronchoalveolar, urinary, and gut/stool samples. Diverse extraction methodologies, polymerase chain reaction and sequencing techniques, and bioinformatic tools will be evaluated, in addition to di","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-06-01T23:48:07.145Z","creation":"2024-11-09T06:22:16.652Z"},"accession":"S-EPMC10918877","cross_references":{"pubmed":["37283269"],"doi":["10.1002/alz.13076"]}}