{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Du Q"],"funding":["the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University","the General program of Chongqing Natural Science Foundation","National Natural Science Foundation of China","the Chongqing Talents Program"],"pagination":["95"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10918897"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Background</h4>The prognosis for hepatocellular carcinoma (HCC) remains suboptimal, characterized by high recurrence and metastasis rates. Although metalloimmunotherapy has shown potential in combating tumor proliferation, recurrence and metastasis, current apoptosis-based metalloimmunotherapy fails to elicit sufficient immune response for HCC.<h4>Results</h4>A smart responsive bimetallic nanovaccine was constructed to induce immunogenic cell death (ICD) through pyroptosis and enhance the efficacy of the cGAS-STING pathway. The nanovaccine was composed of manganese-doped mesoporous silica as a carrier, loaded with sorafenib (SOR) and modified with MIL-100 (Fe), where Fe<sup>3+</sup>, SOR, and Mn<sup>2+</sup> were synchronized and released into the tumor with the help of the tumor microenvironment (TME). Afterward, Fe<sup>3+</sup> worked synergistically with SOR-induced immunogenic pyroptosis (via both the classical and nonclassical signaling pathways), causing the outflow of abundant immunogenic factors, which contributes to dendritic cell (DC) maturation, and the exposure of double-stranded DNA (dsDNA). Subsequently, the exposed dsDNA and Mn<sup>2+</sup> jointly activated the cGAS-STING pathway and induced the release of type I interferons, which further led to DC maturation. Moreover, Mn<sup>2+</sup>-related T1 magnetic resonance imaging (MRI) was used to visually evaluate the smart response functionality of the nanovaccine.<h4>Conclusion</h4>The utilization of metallic nanovaccines to induce pyroptosis-mediated immune activation provides a promising paradigm for HCC treatment."],"journal":["Journal of nanobiotechnology"],"pubmed_title":["Smart responsive Fe/Mn nanovaccine triggers liver cancer immunotherapy via pyroptosis and pyroptosis-boosted cGAS-STING activation."],"pmcid":["PMC10918897"],"funding_grant_id":["81971608","cstc2020jcyj-msxmX1017","82271970","CQYC2020030389, 2020-7","cstc2021ycjh-bgzxm0168"],"pubmed_authors":["Xu L","Du Q","Wang J","Xu J","Zhang W","Liu Y","Du C","Ran H","Luo Y","Liu B","Guo D","Chen S","Wang Y","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Smart responsive Fe/Mn nanovaccine triggers liver cancer immunotherapy via pyroptosis and pyroptosis-boosted cGAS-STING activation.","description":"<h4>Background</h4>The prognosis for hepatocellular carcinoma (HCC) remains suboptimal, characterized by high recurrence and metastasis rates. Although metalloimmunotherapy has shown potential in combating tumor proliferation, recurrence and metastasis, current apoptosis-based metalloimmunotherapy fails to elicit sufficient immune response for HCC.<h4>Results</h4>A smart responsive bimetallic nanovaccine was constructed to induce immunogenic cell death (ICD) through pyroptosis and enhance the efficacy of the cGAS-STING pathway. The nanovaccine was composed of manganese-doped mesoporous silica as a carrier, loaded with sorafenib (SOR) and modified with MIL-100 (Fe), where Fe<sup>3+</sup>, SOR, and Mn<sup>2+</sup> were synchronized and released into the tumor with the help of the tumor microenvironment (TME). Afterward, Fe<sup>3+</sup> worked synergistically with SOR-induced immunogenic pyroptosis (via both the classical and nonclassical signaling pathways), causing the outflow of abundant immunogenic factors, which contributes to dendritic cell (DC) maturation, and the exposure of double-stranded DNA (dsDNA). Subsequently, the exposed dsDNA and Mn<sup>2+</sup> jointly activated the cGAS-STING pathway and induced the release of type I interferons, which further led to DC maturation. Moreover, Mn<sup>2+</sup>-related T1 magnetic resonance imaging (MRI) was used to visually evaluate the smart response functionality of the nanovaccine.<h4>Conclusion</h4>The utilization of metallic nanovaccines to induce pyroptosis-mediated immune activation provides a promising paradigm for HCC treatment.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-12T10:09:55.381Z","creation":"2025-04-04T12:35:35.711Z"},"accession":"S-EPMC10918897","cross_references":{"pubmed":["38448959"],"doi":["10.1186/s12951-024-02354-2"]}}