{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao L"],"funding":["Special funds for comfortable medical anesthesia optimization at Shandong Provincial Medical","China Postdoctoral Science Foundation","Shandong Provincial Natural Science Foundation of China"],"pagination":["120"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10919006"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>A significant reduction in regional cerebral oxygen saturation (rSO<sub>2</sub>) is commonly observed during one-lung ventilation (OLV), while positive end-expiratory pressure (PEEP) can improve oxygenation. We compared the effects of three different PEEP levels on rSO<sub>2</sub>, pulmonary oxygenation, and hemodynamics during OLV.<h4>Methods</h4>Forty-three elderly patients who underwent thoracoscopic lobectomy were randomly assigned to one of six PEEP combinations which used a crossover design of 3 levels of PEEP-0 cmH<sub>2</sub>O, 5 cmH<sub>2</sub>O, and 10 cmH<sub>2</sub>O. The primary endpoint was rSO<sub>2</sub> in patients receiving OLV 20 min after adjusting the PEEP. The secondary outcomes included hemodynamic and respiratory variables.<h4>Results</h4>After exclusion, thirty-six patients (36.11% female; age range: 60-76 year) were assigned to six groups (n = 6 in each group). The rSO<sub>2</sub> was highest at OLV(0) than at OLV(10) (difference, 2.889%; [95% CI, 0.573 to 5.204%]; p = 0.008). Arterial oxygen partial pressure (PaO<sub>2</sub>) was lowest at OLV(0) compared with OLV(5) (difference, -62.639 mmHg; [95% CI, -106.170 to -19.108 mmHg]; p = 0.005) or OLV(10) (difference, -73.389 mmHg; [95% CI, -117.852 to -28.925 mmHg]; p = 0.001), while peak airway pressure (Ppeak) was lower at OLV(0) (difference, -4.222 mmHg; [95% CI, -5.140 to -3.304 mmHg]; p < 0.001) and OLV(5) (difference, -3.139 mmHg; [95% CI, -4.110 to -2.167 mmHg]; p < 0.001) than at OLV(10).<h4>Conclusions</h4>PEEP with 10 cmH<sub>2</sub>O makes rSO<sub>2</sub> decrease compared with 0 cmH<sub>2</sub>O. Applying PEEP with 5 cmH<sub>2</sub>O during OLV in elderly patients can improve oxygenation and maintain high rSO<sub>2</sub> levels, without significantly increasing peak airway pressure compared to not using PEEP.<h4>Trial registration</h4>Chinese Clinical Trial Registry ChiCTR2200060112 on 19 May 2022."],"journal":["BMC pulmonary medicine"],"pubmed_title":["Effects of positive end-expiratory pressure on regional cerebral oxygen saturation in elderly patients undergoing thoracic surgery during one-lung ventilation: a randomized crossover-controlled trial."],"pmcid":["PMC10919006"],"funding_grant_id":["ZR2020MH012","ZR2022MH052","2021M691944","YXH2021ZX015"],"pubmed_authors":["Lu K","Yang X","Wu J","Semel J","Zhao L","Bermea KC","Zhang Y","Lv S","Bai Y","Yi W","Xiao Q"],"additional_accession":[]},"is_claimable":false,"name":"Effects of positive end-expiratory pressure on regional cerebral oxygen saturation in elderly patients undergoing thoracic surgery during one-lung ventilation: a randomized crossover-controlled trial.","description":"<h4>Background</h4>A significant reduction in regional cerebral oxygen saturation (rSO<sub>2</sub>) is commonly observed during one-lung ventilation (OLV), while positive end-expiratory pressure (PEEP) can improve oxygenation. We compared the effects of three different PEEP levels on rSO<sub>2</sub>, pulmonary oxygenation, and hemodynamics during OLV.<h4>Methods</h4>Forty-three elderly patients who underwent thoracoscopic lobectomy were randomly assigned to one of six PEEP combinations which used a crossover design of 3 levels of PEEP-0 cmH<sub>2</sub>O, 5 cmH<sub>2</sub>O, and 10 cmH<sub>2</sub>O. The primary endpoint was rSO<sub>2</sub> in patients receiving OLV 20 min after adjusting the PEEP. The secondary outcomes included hemodynamic and respiratory variables.<h4>Results</h4>After exclusion, thirty-six patients (36.11% female; age range: 60-76 year) were assigned to six groups (n = 6 in each group). The rSO<sub>2</sub> was highest at OLV(0) than at OLV(10) (difference, 2.889%; [95% CI, 0.573 to 5.204%]; p = 0.008). Arterial oxygen partial pressure (PaO<sub>2</sub>) was lowest at OLV(0) compared with OLV(5) (difference, -62.639 mmHg; [95% CI, -106.170 to -19.108 mmHg]; p = 0.005) or OLV(10) (difference, -73.389 mmHg; [95% CI, -117.852 to -28.925 mmHg]; p = 0.001), while peak airway pressure (Ppeak) was lower at OLV(0) (difference, -4.222 mmHg; [95% CI, -5.140 to -3.304 mmHg]; p < 0.001) and OLV(5) (difference, -3.139 mmHg; [95% CI, -4.110 to -2.167 mmHg]; p < 0.001) than at OLV(10).<h4>Conclusions</h4>PEEP with 10 cmH<sub>2</sub>O makes rSO<sub>2</sub> decrease compared with 0 cmH<sub>2</sub>O. Applying PEEP with 5 cmH<sub>2</sub>O during OLV in elderly patients can improve oxygenation and maintain high rSO<sub>2</sub> levels, without significantly increasing peak airway pressure compared to not using PEEP.<h4>Trial registration</h4>Chinese Clinical Trial Registry ChiCTR2200060112 on 19 May 2022.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-12T10:08:48.87Z","creation":"2025-04-04T12:34:50.157Z"},"accession":"S-EPMC10919006","cross_references":{"pubmed":["38448844"],"doi":["10.1186/s12890-024-02931-z"]}}