biostudies-literatureZhao LSpecial funds for comfortable medical anesthesia optimization at Shandong Provincial MedicalChina Postdoctoral Science FoundationShandong Provincial Natural Science Foundation of China120https://www.ebi.ac.uk/biostudies/studies/S-EPMC10919006biostudies-literatureUnknown24(1)<h4>Background</h4>A significant reduction in regional cerebral oxygen saturation (rSO₂) is commonly observed during one-lung ventilation (OLV), while positive end-expiratory pressure (PEEP) can improve oxygenation. We compared the effects of three different PEEP levels on rSO₂, pulmonary oxygenation, and hemodynamics during OLV.<h4>Methods</h4>Forty-three elderly patients who underwent thoracoscopic lobectomy were randomly assigned to one of six PEEP combinations which used a crossover design of 3 levels of PEEP-0 cmH₂O, 5 cmH₂O, and 10 cmH₂O. The primary endpoint was rSO₂ in patients receiving OLV 20 min after adjusting the PEEP. The secondary outcomes included hemodynamic and respiratory variables.<h4>Results</h4>After exclusion, thirty-six patients (36.11% female; age range: 60-76 year) were assigned to six groups (n = 6 in each group). The rSO₂ was highest at OLV(0) than at OLV(10) (difference, 2.889%; [95% CI, 0.573 to 5.204%]; p = 0.008). Arterial oxygen partial pressure (PaO₂) was lowest at OLV(0) compared with OLV(5) (difference, -62.639 mmHg; [95% CI, -106.170 to -19.108 mmHg]; p = 0.005) or OLV(10) (difference, -73.389 mmHg; [95% CI, -117.852 to -28.925 mmHg]; p = 0.001), while peak airway pressure (Ppeak) was lower at OLV(0) (difference, -4.222 mmHg; [95% CI, -5.140 to -3.304 mmHg]; p < 0.001) and OLV(5) (difference, -3.139 mmHg; [95% CI, -4.110 to -2.167 mmHg]; p < 0.001) than at OLV(10).<h4>Conclusions</h4>PEEP with 10 cmH₂O makes rSO₂ decrease compared with 0 cmH₂O. Applying PEEP with 5 cmH₂O during OLV in elderly patients can improve oxygenation and maintain high rSO₂ levels, without significantly increasing peak airway pressure compared to not using PEEP.<h4>Trial registration</h4>Chinese Clinical Trial Registry ChiCTR2200060112 on 19 May 2022.BMC pulmonary medicineEffects of positive end-expiratory pressure on regional cerebral oxygen saturation in elderly patients undergoing thoracic surgery during one-lung ventilation: a randomized crossover-controlled trial.PMC10919006ZR2020MH012ZR2022MH0522021M691944YXH2021ZX015Lu KYang XWu JSemel JZhao LBermea KCZhang YLv SBai YYi WXiao QfalseEffects of positive end-expiratory pressure on regional cerebral oxygen saturation in elderly patients undergoing thoracic surgery during one-lung ventilation: a randomized crossover-controlled trial.<h4>Background</h4>A significant reduction in regional cerebral oxygen saturation (rSO₂) is commonly observed during one-lung ventilation (OLV), while positive end-expiratory pressure (PEEP) can improve oxygenation. We compared the effects of three different PEEP levels on rSO₂, pulmonary oxygenation, and hemodynamics during OLV.<h4>Methods</h4>Forty-three elderly patients who underwent thoracoscopic lobectomy were randomly assigned to one of six PEEP combinations which used a crossover design of 3 levels of PEEP-0 cmH₂O, 5 cmH₂O, and 10 cmH₂O. The primary endpoint was rSO₂ in patients receiving OLV 20 min after adjusting the PEEP. The secondary outcomes included hemodynamic and respiratory variables.<h4>Results</h4>After exclusion, thirty-six patients (36.11% female; age range: 60-76 year) were assigned to six groups (n = 6 in each group). The rSO₂ was highest at OLV(0) than at OLV(10) (difference, 2.889%; [95% CI, 0.573 to 5.204%]; p = 0.008). Arterial oxygen partial pressure (PaO₂) was lowest at OLV(0) compared with OLV(5) (difference, -62.639 mmHg; [95% CI, -106.170 to -19.108 mmHg]; p = 0.005) or OLV(10) (difference, -73.389 mmHg; [95% CI, -117.852 to -28.925 mmHg]; p = 0.001), while peak airway pressure (Ppeak) was lower at OLV(0) (difference, -4.222 mmHg; [95% CI, -5.140 to -3.304 mmHg]; p < 0.001) and OLV(5) (difference, -3.139 mmHg; [95% CI, -4.110 to -2.167 mmHg]; p < 0.001) than at OLV(10).<h4>Conclusions</h4>PEEP with 10 cmH₂O makes rSO₂ decrease compared with 0 cmH₂O. Applying PEEP with 5 cmH₂O during OLV in elderly patients can improve oxygenation and maintain high rSO₂ levels, without significantly increasing peak airway pressure compared to not using PEEP.<h4>Trial registration</h4>Chinese Clinical Trial Registry ChiCTR2200060112 on 19 May 2022.2024-01-01T00:00:00Z2024 Mar2026-06-12T10:08:48.87Z2025-04-04T12:34:50.157ZS-EPMC109190063844884410.1186/s12890-024-02931-z