biostudies-literatureCao L345 Talent Project of Shengjing Hospital of China Medical UniversityNational Natural Science Foundation of ChinaYong Elite Scientist Sponsorship Program by CastTianjin Health Research ProgramBeijing Chao-Yang Hospital Golden Seeds Foundation101https://www.ebi.ac.uk/biostudies/studies/S-EPMC10919055biostudies-literatureUnknown22(1)<h4>Background</h4>Non-alcoholic fatty liver disease (NAFLD) and metabolic-associated fatty liver disease (MAFLD) shares common pathophysiological mechanisms with type 2 diabetes, making them significant risk factors for type 2 diabetes. The present study aimed to assess the epidemiological feature of type 2 diabetes in patients with NAFLD or MAFLD at global levels.<h4>Methods</h4>Published studies were searched for terms that included type 2 diabetes, and NAFLD or MAFLD using PubMed, EMBASE, MEDLINE, and Web of Science databases from their inception to December 2022. The pooled global and regional prevalence and incidence density of type 2 diabetes in patients with NAFLD or MAFLD were evaluated using random-effects meta-analysis. Potential sources of heterogeneity were investigated using BMC medicineGlobal epidemiology of type 2 diabetes in patients with NAFLD or MAFLD: a systematic review and meta-analysis.PMC1091905582003456M0294CYJZ2021022020QNRC00182103811TJWJ2022QN043Cao LLiu HXia YJiang JShi MLu YLv YChen LDai WZhou YZhao YLiu WAn YfalseGlobal epidemiology of type 2 diabetes in patients with NAFLD or MAFLD: a systematic review and meta-analysis.<h4>Background</h4>Non-alcoholic fatty liver disease (NAFLD) and metabolic-associated fatty liver disease (MAFLD) shares common pathophysiological mechanisms with type 2 diabetes, making them significant risk factors for type 2 diabetes. The present study aimed to assess the epidemiological feature of type 2 diabetes in patients with NAFLD or MAFLD at global levels.<h4>Methods</h4>Published studies were searched for terms that included type 2 diabetes, and NAFLD or MAFLD using PubMed, EMBASE, MEDLINE, and Web of Science databases from their inception to December 2022. The pooled global and regional prevalence and incidence density of type 2 diabetes in patients with NAFLD or MAFLD were evaluated using random-effects meta-analysis. Potential sources of heterogeneity were investigated using 2024-01-01T00:00:00Z2024 Mar2025-04-04T12:34:48.737Z2025-04-04T12:34:48.737ZS-EPMC109190553844894310.1186/s12916-024-03315-0