{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Arends T"],"funding":["Seattle Children’s Cancer Consortium","Fred Hutch","National Institutes of Health","National Institute of General Medical Sciences","Friends of FSH Research","National Institutes of Arthritis and Musculoskeletal and Skin Diseases","University of Washington","National Cancer Institute","NCI NIH HHS","NIAMS NIH HHS","Ovarian Cancer Research Alliance","NIH HHS","NIGMS NIH HHS"],"pagination":["e202303141"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10919155"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["223(5)"],"pubmed_abstract":["Polycomb repressive complexes regulate developmental gene programs, promote DNA damage repair, and mediate pericentromeric satellite repeat repression. Expression of pericentromeric satellite repeats has been implicated in several cancers and diseases, including facioscapulohumeral dystrophy (FSHD). Here, we show that DUX4-mediated transcription of HSATII regions causes nuclear foci formation of KDM2A/B-PRC1 complexes, resulting in a global loss of PRC1-mediated monoubiquitination of histone H2A. Loss of PRC1-ubiquitin signaling severely impacts DNA damage response. Our data implicate DUX4-activation of HSATII and sequestration of KDM2A/B-PRC1 complexes as a mechanism of regulating epigenetic and DNA repair pathways."],"journal":["The Journal of cell biology"],"pubmed_title":["DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response."],"pmcid":["PMC10919155"],"funding_grant_id":["R01AR045203","T32 CA009657","R35 GM150532","P30CA015704","T32CA009657","P30 CA015704","R01 AR045203","R35GM150532"],"pubmed_authors":["Adeyemi RO","Arends T","Tsuchida H","Tapscott SJ"],"additional_accession":[]},"is_claimable":false,"name":"DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response.","description":"Polycomb repressive complexes regulate developmental gene programs, promote DNA damage repair, and mediate pericentromeric satellite repeat repression. Expression of pericentromeric satellite repeats has been implicated in several cancers and diseases, including facioscapulohumeral dystrophy (FSHD). Here, we show that DUX4-mediated transcription of HSATII regions causes nuclear foci formation of KDM2A/B-PRC1 complexes, resulting in a global loss of PRC1-mediated monoubiquitination of histone H2A. Loss of PRC1-ubiquitin signaling severely impacts DNA damage response. Our data implicate DUX4-activation of HSATII and sequestration of KDM2A/B-PRC1 complexes as a mechanism of regulating epigenetic and DNA repair pathways.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-01T13:24:44.777Z","creation":"2025-04-05T13:58:31.863Z"},"accession":"S-EPMC10919155","cross_references":{"pubmed":["38451221"],"doi":["10.1083/jcb.202303141"]}}