{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Maier KB"],"funding":["NIBIB NIH HHS","National Science Foundation Graduate Research Fellowship Program","National Institute of General Medical Sciences","National Institute of Biomedical Imaging and Bioengineering","NIGMS NIH HHS","National Science Foundation"],"pagination":["2898-2901"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10919327"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["60(21)"],"pubmed_abstract":["Enhancing the performance of Gd<sup>3+</sup> chelates as relaxation agents for MRI has the potential to lower doses, improving safety and mitigating the environmental impact on our surface waters. More than three decades of research into manipulating the properties of Gd<sup>3+</sup> have failed to develop a chelate that simultaneously optimizes all relevant parameters and affords maximal relaxivity. Introducing aryl substituents into the α-position of the pendant arms of a GdDOTA chelate affords chelates that, for the first time, simultaneously optimize all physico-chemical properties. Slowing tumbling by binding to human serum albumin affords a relaxivity of 110 ± 5 mM<sup>-1</sup> s<sup>-1</sup>, close to the maximum possible. As discrete chelates, these α-aryl substituted GdDOTA chelates exhibit relaxivities that are 2-3 times higher than those of currently used agents, even at the higher fields (1.5 & 3.0 T) used in modern clinical MRI."],"journal":["Chemical communications (Cambridge, England)"],"pubmed_title":["α-Aryl substituted GdDOTA derivatives, the perfect contrast agents for MRI?"],"pmcid":["PMC10919327"],"funding_grant_id":["R03 EB034082","034082","MRI 1828573","GM-127964","EB-034082","R21 GM127964"],"pubmed_authors":["Woods M","Rust LN","Maier KB","Carniato F","Botta M"],"additional_accession":[]},"is_claimable":false,"name":"α-Aryl substituted GdDOTA derivatives, the perfect contrast agents for MRI?","description":"Enhancing the performance of Gd<sup>3+</sup> chelates as relaxation agents for MRI has the potential to lower doses, improving safety and mitigating the environmental impact on our surface waters. More than three decades of research into manipulating the properties of Gd<sup>3+</sup> have failed to develop a chelate that simultaneously optimizes all relevant parameters and affords maximal relaxivity. Introducing aryl substituents into the α-position of the pendant arms of a GdDOTA chelate affords chelates that, for the first time, simultaneously optimize all physico-chemical properties. Slowing tumbling by binding to human serum albumin affords a relaxivity of 110 ± 5 mM<sup>-1</sup> s<sup>-1</sup>, close to the maximum possible. As discrete chelates, these α-aryl substituted GdDOTA chelates exhibit relaxivities that are 2-3 times higher than those of currently used agents, even at the higher fields (1.5 & 3.0 T) used in modern clinical MRI.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-04T12:34:41.62Z","creation":"2025-04-04T12:34:41.62Z"},"accession":"S-EPMC10919327","cross_references":{"pubmed":["38234268"],"doi":["10.1039/d3cc05989h"]}}