biostudies-literatureUnknown95(4)Filippa M<h4>Background</h4>Premature birth is known to affect the newborn's autonomic nervous system (ANS) maturation, with potential short and long-term impact on their neurobehavioral development. The purpose of the study was to investigate the effects of maternal directed singing and speaking on the preterm infants' autonomic nervous system (ANS) maturation as measured by the heart rate variability (HRV) parameters.<h4>Methods</h4>In this multi-center randomized clinical trial, 30 stable preterm infants (m = 29,6 weeks of gestational age), without any abnormalities were randomized into an intervention (16) or a control group (14). HRV was measured weekly, for a total of 80 recordings during hospitalization, as well as before and after each session of singing or speaking.<h4>Results</h4>The intePediatric research1110-1116https://www.ebi.ac.uk/biostudies/studies/S-EPMC10920191biostudies-literatureMaternal singing sustains preterm hospitalized newborns' autonomic nervous system maturation: an RCT.PMC10920191EVC GroupBertoncelli NSansavini AMeloni SPicciolini OCorvaglia LPetrolini CGrandjean DZuccarini MBedetti LDella Casa ELucco GFilippa MCecchi AAceti AScilingo EPLuzzati MNardelli MFerrari FBerardi AOri LLunardi CfalseMaternal singing sustains preterm hospitalized newborns' autonomic nervous system maturation: an RCT.<h4>Background</h4>Premature birth is known to affect the newborn's autonomic nervous system (ANS) maturation, with potential short and long-term impact on their neurobehavioral development. The purpose of the study was to investigate the effects of maternal directed singing and speaking on the preterm infants' autonomic nervous system (ANS) maturation as measured by the heart rate variability (HRV) parameters.<h4>Methods</h4>In this multi-center randomized clinical trial, 30 stable preterm infants (m = 29,6 weeks of gestational age), without any abnormalities were randomized into an intervention (16) or a control group (14). HRV was measured weekly, for a total of 80 recordings during hospitalization, as well as before and after each session of singing or speaking.<h4>Results</h4>The inte2024-01-01T00:00:00Z2024 Mar2026-07-15T11:49:56.386Z2026-07-06T03:08:43.646ZS-EPMC109201913805757410.1038/s41390-023-02932-4