biostudies-literatureLlamosas-Falcon LNational Institute on Alcohol Abuse and AlcoholismNIAAA NIH HHS216-224https://www.ebi.ac.uk/biostudies/studies/S-EPMC10920389biostudies-literatureUnknown18(1)<h4>Background</h4>Alcohol consumption is the most important risk factor responsible for the disease burden of liver cirrhosis (LC). Estimates of risk relationships available usually neither distinguish between different causes such as alcohol-related LC or hepatitis-related LC, nor differentiate between morbidity and mortality as outcome. We aimed to address this research gap and identify dose-response relationships between alcohol consumption and LC, by cause and outcome.<h4>Methods</h4>A systematic review using PubMed/Medline and Embase was conducted, identifying studies that reported an association between level of alcohol use and LC. Meta-regression models were used to estimate the dose-response relationships and control for heterogeneity.<h4>Results</h4>Totally, 44 studies, and 1 secHepatology internationalHow does alcohol use impact morbidity and mortality of liver cirrhosis? A systematic review and dose-response meta-analysis.PMC10920389R01AA028009R01 AA028224R01AA028224R01 AA028009Probst CPuka KZhu YBuckley CJiang HLasserre AMTran ALlamosas-Falcon LRehm JfalseHow does alcohol use impact morbidity and mortality of liver cirrhosis? A systematic review and dose-response meta-analysis.<h4>Background</h4>Alcohol consumption is the most important risk factor responsible for the disease burden of liver cirrhosis (LC). Estimates of risk relationships available usually neither distinguish between different causes such as alcohol-related LC or hepatitis-related LC, nor differentiate between morbidity and mortality as outcome. We aimed to address this research gap and identify dose-response relationships between alcohol consumption and LC, by cause and outcome.<h4>Methods</h4>A systematic review using PubMed/Medline and Embase was conducted, identifying studies that reported an association between level of alcohol use and LC. Meta-regression models were used to estimate the dose-response relationships and control for heterogeneity.<h4>Results</h4>Totally, 44 studies, and 1 sec2024-01-01T00:00:00Z2024 Feb2025-04-03T23:22:19.586Z2025-04-03T23:22:19.586ZS-EPMC109203893768442410.1007/s12072-023-10584-z