{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Duarte ABS"],"funding":["Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","Fundação de Apoio à Pesquisa do Estado da Paraíba"],"pagination":["25-39"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10920570"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["55(1)"],"pubmed_abstract":["The objective of this study was to evaluate the antifungal activity of free methyl 3,5 dinitrobenzoate (MDNB) and its nanoemulsion (MDNB-NE) against strains of Candida albicans. Additionally, a molecular modeling study was also carried out to propose the mechanism of action and toxicity of MDNB. These results demonstrated the MDNB-NE presented a droplet size of 181.16 ± 3.20 nm and polydispersity index of 0.30 ± 0.03. MDNB and MDNB-NE inhibited the growth of all strains with minimum inhibitory concentrations of 0.27-1.10 mM. The biological results corroborated the molecular model, which pointed to a multi-target antifungal mechanism of action for MDNB in C. albicans. The study could serve as a basis for further research involving compounds with nitro groups with antifungal."],"journal":["Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]"],"pubmed_title":["Antifungal activity against Candida albicans of methyl 3,5-dinitrobenzoate loaded nanoemulsion."],"pmcid":["PMC10920570"],"funding_grant_id":["001"],"pubmed_authors":["Perez-Castillo Y","Oliveira EE","de Souza RL","Duarte ABS","de Castro RD","de Sousa DP","da Nobrega Alves D"],"additional_accession":[]},"is_claimable":false,"name":"Antifungal activity against Candida albicans of methyl 3,5-dinitrobenzoate loaded nanoemulsion.","description":"The objective of this study was to evaluate the antifungal activity of free methyl 3,5 dinitrobenzoate (MDNB) and its nanoemulsion (MDNB-NE) against strains of Candida albicans. Additionally, a molecular modeling study was also carried out to propose the mechanism of action and toxicity of MDNB. These results demonstrated the MDNB-NE presented a droplet size of 181.16 ± 3.20 nm and polydispersity index of 0.30 ± 0.03. MDNB and MDNB-NE inhibited the growth of all strains with minimum inhibitory concentrations of 0.27-1.10 mM. The biological results corroborated the molecular model, which pointed to a multi-target antifungal mechanism of action for MDNB in C. albicans. The study could serve as a basis for further research involving compounds with nitro groups with antifungal.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-02T03:21:10.543Z","creation":"2025-04-07T00:26:58.736Z"},"accession":"S-EPMC10920570","cross_references":{"pubmed":["38135805"],"doi":["10.1007/s42770-023-01214-9"]}}