{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ali M"],"funding":["Fonds National de la Recherche Luxembourg","Fonds National de la Recherche Luxembourg (National Research Fund)"],"pagination":["119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10920792"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["Alzheimer's disease (AD) progression and pathology show pronounced sex differences, but the factors driving these remain poorly understood. To gain insights into early AD-associated molecular changes and their sex dependency for tau pathology in the cortex, we performed single-cell RNA-seq in the THY-Tau22 AD mouse model. By examining cell type-specific and cell type-agnostic AD-related gene activity changes and their sex-dimorphism for individual genes, pathways and cellular sub-networks, we identified both statistically significant alterations and interpreted the upstream mechanisms controlling them. Our results confirm several significant sex-dependent alterations in gene activity in the THY-Tau22 model mice compared to controls, with more pronounced alterations in females. Both changes"],"journal":["Cell death discovery"],"pubmed_title":["Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer's disease reveals sex-dependent dysregulations."],"pmcid":["PMC10920792"],"funding_grant_id":["INTER/22/17104370","ERAPERMED 2020-314"],"pubmed_authors":["Buee L","Sciortino A","Skupin A","Glaab E","Heurtaux T","Ali M","Coowar D","Blum D","Garcia P","Buttini M","Grzyb K","Lunkes LP","Thomas M","Halder R"],"additional_accession":[]},"is_claimable":false,"name":"Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer's disease reveals sex-dependent dysregulations.","description":"Alzheimer's disease (AD) progression and pathology show pronounced sex differences, but the factors driving these remain poorly understood. To gain insights into early AD-associated molecular changes and their sex dependency for tau pathology in the cortex, we performed single-cell RNA-seq in the THY-Tau22 AD mouse model. By examining cell type-specific and cell type-agnostic AD-related gene activity changes and their sex-dimorphism for individual genes, pathways and cellular sub-networks, we identified both statistically significant alterations and interpreted the upstream mechanisms controlling them. Our results confirm several significant sex-dependent alterations in gene activity in the THY-Tau22 model mice compared to controls, with more pronounced alterations in females. Both changes","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-15T13:50:26.67Z","creation":"2026-07-05T03:11:21.159Z"},"accession":"S-EPMC10920792","cross_references":{"pubmed":["38453894"],"doi":["10.1038/s41420-024-01885-9"]}}