{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Elisia I"],"funding":["The Lotte and John Hecht Memorial Foundation"],"pagination":["5610"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10920871"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Given that ketogenic diets (KDs) are extremely high in dietary fat, we compared different fats in KDs to determine which was the best for cancer prevention. Specifically, we compared a Western and a 15% carbohydrate diet to seven different KDs, containing either Western fats or fats enriched in medium chain fatty acids (MCTs), milk fat (MF), palm oil (PO), olive oil (OO), corn oil (CO) or fish oil (FO) for their ability to reduce nicotine-derived nitrosamine ketone (NNK)-induced lung cancer in mice. While all the KDs tested were more effective at reducing lung nodules than the Western or 15% carbohydrate diet, the FO-KD was most effective at reducing lung nodules. Correlating with this, mice on the FO-KD had low blood glucose and the highest β-hydroxybutyrate level, lowest liver fatty acid"],"journal":["Scientific reports"],"pubmed_title":["A ketogenic diet rich in fish oil is superior to other fats in preventing NNK-induced lung cancer in A/J mice."],"pmcid":["PMC10920871"],"funding_grant_id":["4340"],"pubmed_authors":["Tee J","Sorensen PH","Shyp T","Elisia I","Dyer R","Yeung M","Wong A","King J","Krystal G","Kowalski S","Hollman S"],"additional_accession":[]},"is_claimable":false,"name":"A ketogenic diet rich in fish oil is superior to other fats in preventing NNK-induced lung cancer in A/J mice.","description":"Given that ketogenic diets (KDs) are extremely high in dietary fat, we compared different fats in KDs to determine which was the best for cancer prevention. Specifically, we compared a Western and a 15% carbohydrate diet to seven different KDs, containing either Western fats or fats enriched in medium chain fatty acids (MCTs), milk fat (MF), palm oil (PO), olive oil (OO), corn oil (CO) or fish oil (FO) for their ability to reduce nicotine-derived nitrosamine ketone (NNK)-induced lung cancer in mice. While all the KDs tested were more effective at reducing lung nodules than the Western or 15% carbohydrate diet, the FO-KD was most effective at reducing lung nodules. Correlating with this, mice on the FO-KD had low blood glucose and the highest β-hydroxybutyrate level, lowest liver fatty acid","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-15T01:54:23.954Z","creation":"2026-06-27T03:18:28.454Z"},"accession":"S-EPMC10920871","cross_references":{"pubmed":["38453966"],"doi":["10.1038/s41598-024-55167-6"]}}