biostudies-literatureLai MNCATS NIH HHSNIDDK NIH HHSNIA NIH HHSNIAID NIH HHSNHLBI NIH HHSNIMH NIH HHS465-475https://www.ebi.ac.uk/biostudies/studies/S-EPMC10922264biostudies-literatureUnknown38(4)<h4>Objective</h4>The aim of this study was to determine whether urine biomarkers of kidney health are associated with subclinical cardiovascular disease among men with and without HIV.<h4>Design</h4>A cross-sectional study within the Multicenter AIDS Cohort Study (MACS) among 504 men with and without HIV infection who underwent cardiac computed tomography scans and had urine biomarkers measured within the preceding 2 years.<h4>Methods</h4>Our primary predictors were four urine biomarkers of endothelial (albuminuria), proximal tubule dysfunction (alpha-1-microglobulin [A1 M] and injury (kidney injury molecule-1 [KIM-1]) and tubulointerstitial fibrosis (pro-collagen-III N-terminal peptide [PIIINP]). These were evaluated for association with coronary artery calcium (CAC) prevalence, CAC extent, total plaque score, and total segment stenosis using multivariable regression.<h4>Results</h4>Of the 504 participants, 384 were men with HIV (MWH) and 120 were men without HIV. In models adjusted for sociodemographic factors, cardiovascular disease risk factors, eGFR, and HIV-related factors, each two-fold higher concentration of albuminuria was associated with a greater extent of CAC (1.35-fold higher, 95% confidence interval 1.11-1.65), and segment stenosis (1.08-fold greater, 95% confidence interval 1.01-1.16). Associations were similar between MWH and men without HIV in stratified analyses. The third quartile of A1 M showed an association with greater CAC extent, total plaque score, and total segment stenosis, compared with the lowest quartile.<h4>Conclusion</h4>Worse endothelial and proximal tubule dysfunction, as reflected by higher urine albumin and A1 M, were associated with greater CAC extent and coronary artery stenosis.AIDS (London, England)Association of urine biomarkers of kidney health with subclinical cardiovascular disease among men with and without HIV.PMC10922264P30 AI050410R01 AG034853UL1 TR001881U01 HL146205U01 HL146204U01 HL146203U01 HL146208U01 DK114866U01 HL146242U01 HL146241U01 HL146240UL1 TR001409KL2 TR001432U01 HL146202R01 HL085757U01 HL146245U01 HL146201TL1 TR001871TL1 TR001431P30 MH116867P30 AI027767P30 AI073961UL1 TR003098UL1 TR000004R01 HL095129P30 DK079310P30 AI050409U01 HL146333R01 DK093770U01 DK106962U01 DK129984U01 HL146194U01 HL146193U01 HL146192Shlipak MGWolinsky SMWitt MDMadden EHo KScherzer RParikh CREstrella MMBrown TTAbraham AGPost WSVittinghoff EHaberlen SBudoff MLai MfalseAssociation of urine biomarkers of kidney health with subclinical cardiovascular disease among men with and without HIV.<h4>Objective</h4>The aim of this study was to determine whether urine biomarkers of kidney health are associated with subclinical cardiovascular disease among men with and without HIV.<h4>Design</h4>A cross-sectional study within the Multicenter AIDS Cohort Study (MACS) among 504 men with and without HIV infection who underwent cardiac computed tomography scans and had urine biomarkers measured within the preceding 2 years.<h4>Methods</h4>Our primary predictors were four urine biomarkers of endothelial (albuminuria), proximal tubule dysfunction (alpha-1-microglobulin [A1 M] and injury (kidney injury molecule-1 [KIM-1]) and tubulointerstitial fibrosis (pro-collagen-III N-terminal peptide [PIIINP]). These were evaluated for association with coronary artery calcium (CAC) prevalence, CAC extent, total plaque score, and total segment stenosis using multivariable regression.<h4>Results</h4>Of the 504 participants, 384 were men with HIV (MWH) and 120 were men without HIV. In models adjusted for sociodemographic factors, cardiovascular disease risk factors, eGFR, and HIV-related factors, each two-fold higher concentration of albuminuria was associated with a greater extent of CAC (1.35-fold higher, 95% confidence interval 1.11-1.65), and segment stenosis (1.08-fold greater, 95% confidence interval 1.01-1.16). Associations were similar between MWH and men without HIV in stratified analyses. The third quartile of A1 M showed an association with greater CAC extent, total plaque score, and total segment stenosis, compared with the lowest quartile.<h4>Conclusion</h4>Worse endothelial and proximal tubule dysfunction, as reflected by higher urine albumin and A1 M, were associated with greater CAC extent and coronary artery stenosis.2024-01-01T00:00:00Z2024 Mar2025-04-04T01:29:31.381Z2025-04-04T01:29:31.381ZS-EPMC109222643786168910.1097/QAD.000000000000376110.1097/qad.0000000000003761