{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lo GH"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","GlaxoSmithKline","Novartis Pharmaceuticals Corporation","NIA NIH HHS","Pfizer","NHLBI NIH HHS","NIH","NIAMS NIH HHS","NIH HHS"],"pagination":["377-383"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10922276"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["76(3)"],"pubmed_abstract":["<h4>Objective</h4>We aimed to evaluate the relationship of a history of strength training with symptomatic and structural outcomes of knee osteoarthritis (OA).<h4>Methods</h4>This study was a retrospective, cross-sectional study within the Osteoarthritis Initiative (OAI), a multicenter prospective longitudinal observational study. Data were collected at four OAI clinical sites: Memorial Hospital of Rhode Island, the Ohio State University, the University of Pittsburgh, and the University of Maryland/Johns Hopkins. The study included 2,607 participants with complete data on strength training, knee pain, and radiographic evidence of knee OA (male, 44.2%; mean ± SD age 64.3 ± 9.0 years; mean ± SD body mass index 28.5 ± 4.9 kg/m<sup>2</sup> ). We used a self-administered questionnaire at the 96-month OAI visit to evaluate the exposure of strength training participation during four time periods throughout a participant's lifetime (ages 12-18, 19-34, 35-49, and ≥50 years old). The outcomes (dependent variables) were radiographic OA (ROA), symptomatic radiographic OA (SOA), and frequent knee pain.<h4>Results</h4>The fully adjusted odds ratios (95% confidence interval) for frequent knee pain, ROA, and SOA among those who participated in strength training any time in their lives were 0.82 (0.68-0.97), 0.83 (0.70-0.99), and 0.77 (0.63-0.94), respectively. Findings were similar when looking at the specific age ranges.<h4>Conclusion</h4>Strength training is beneficial for future knee health, counteracting long-held assumptions that strength training has adverse effects."],"journal":["Arthritis & rheumatology (Hoboken, N.J.)"],"pubmed_title":["Strength Training Is Associated With Less Knee Osteoarthritis: Data From the Osteoarthritis Initiative."],"pmcid":["PMC10922276"],"funding_grant_id":["N01‐AR‐2‐2259","N01AR22261","K23 AR062127","N01AR22260","N01AR22262","P30 AG028747","N01-AR-2-2261","N01-AR-2-2262","N01‐AR‐2‐2261","N01-AR-2-2260","N01‐AR‐2‐2260","N01-AR-2-2258","N01‐AR‐2‐2262","N01-AR-2-2259","N01‐AR‐2‐2258","N01AR22258","N01AR22259"],"pubmed_authors":["Driban JB","Rockette-Wagner B","Kwoh CK","McAlindon TE","Price LL","Eaton CB","Richard MJ","Nevitt MC","Kriska AM","Lo GH","Hochberg MC"],"additional_accession":[]},"is_claimable":false,"name":"Strength Training Is Associated With Less Knee Osteoarthritis: Data From the Osteoarthritis Initiative.","description":"<h4>Objective</h4>We aimed to evaluate the relationship of a history of strength training with symptomatic and structural outcomes of knee osteoarthritis (OA).<h4>Methods</h4>This study was a retrospective, cross-sectional study within the Osteoarthritis Initiative (OAI), a multicenter prospective longitudinal observational study. Data were collected at four OAI clinical sites: Memorial Hospital of Rhode Island, the Ohio State University, the University of Pittsburgh, and the University of Maryland/Johns Hopkins. The study included 2,607 participants with complete data on strength training, knee pain, and radiographic evidence of knee OA (male, 44.2%; mean ± SD age 64.3 ± 9.0 years; mean ± SD body mass index 28.5 ± 4.9 kg/m<sup>2</sup> ). We used a self-administered questionnaire at the 96-month OAI visit to evaluate the exposure of strength training participation during four time periods throughout a participant's lifetime (ages 12-18, 19-34, 35-49, and ≥50 years old). The outcomes (dependent variables) were radiographic OA (ROA), symptomatic radiographic OA (SOA), and frequent knee pain.<h4>Results</h4>The fully adjusted odds ratios (95% confidence interval) for frequent knee pain, ROA, and SOA among those who participated in strength training any time in their lives were 0.82 (0.68-0.97), 0.83 (0.70-0.99), and 0.77 (0.63-0.94), respectively. Findings were similar when looking at the specific age ranges.<h4>Conclusion</h4>Strength training is beneficial for future knee health, counteracting long-held assumptions that strength training has adverse effects.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-04T19:27:01.115Z","creation":"2025-04-04T19:27:01.115Z"},"accession":"S-EPMC10922276","cross_references":{"pubmed":["37870119"],"doi":["10.1002/art.42732"]}}