biostudies-literatureLo GHNational Institute of Arthritis and Musculoskeletal and Skin DiseasesGlaxoSmithKlineNovartis Pharmaceuticals CorporationNIA NIH HHSPfizerNHLBI NIH HHSNIHNIAMS NIH HHSNIH HHS377-383https://www.ebi.ac.uk/biostudies/studies/S-EPMC10922276biostudies-literatureUnknown76(3)<h4>Objective</h4>We aimed to evaluate the relationship of a history of strength training with symptomatic and structural outcomes of knee osteoarthritis (OA).<h4>Methods</h4>This study was a retrospective, cross-sectional study within the Osteoarthritis Initiative (OAI), a multicenter prospective longitudinal observational study. Data were collected at four OAI clinical sites: Memorial Hospital of Rhode Island, the Ohio State University, the University of Pittsburgh, and the University of Maryland/Johns Hopkins. The study included 2,607 participants with complete data on strength training, knee pain, and radiographic evidence of knee OA (male, 44.2%; mean ± SD age 64.3 ± 9.0 years; mean ± SD body mass index 28.5 ± 4.9 kg/m² ). We used a self-administered questionnaire at the 96-month OAI visit to evaluate the exposure of strength training participation during four time periods throughout a participant's lifetime (ages 12-18, 19-34, 35-49, and ≥50 years old). The outcomes (dependent variables) were radiographic OA (ROA), symptomatic radiographic OA (SOA), and frequent knee pain.<h4>Results</h4>The fully adjusted odds ratios (95% confidence interval) for frequent knee pain, ROA, and SOA among those who participated in strength training any time in their lives were 0.82 (0.68-0.97), 0.83 (0.70-0.99), and 0.77 (0.63-0.94), respectively. Findings were similar when looking at the specific age ranges.<h4>Conclusion</h4>Strength training is beneficial for future knee health, counteracting long-held assumptions that strength training has adverse effects.Arthritis & rheumatology (Hoboken, N.J.)Strength Training Is Associated With Less Knee Osteoarthritis: Data From the Osteoarthritis Initiative.PMC10922276N01‐AR‐2‐2259N01AR22261K23 AR062127N01AR22260N01AR22262P30 AG028747N01-AR-2-2261N01-AR-2-2262N01‐AR‐2‐2261N01-AR-2-2260N01‐AR‐2‐2260N01-AR-2-2258N01‐AR‐2‐2262N01-AR-2-2259N01‐AR‐2‐2258N01AR22258N01AR22259Driban JBRockette-Wagner BKwoh CKMcAlindon TEPrice LLEaton CBRichard MJNevitt MCKriska AMLo GHHochberg MCfalseStrength Training Is Associated With Less Knee Osteoarthritis: Data From the Osteoarthritis Initiative.<h4>Objective</h4>We aimed to evaluate the relationship of a history of strength training with symptomatic and structural outcomes of knee osteoarthritis (OA).<h4>Methods</h4>This study was a retrospective, cross-sectional study within the Osteoarthritis Initiative (OAI), a multicenter prospective longitudinal observational study. Data were collected at four OAI clinical sites: Memorial Hospital of Rhode Island, the Ohio State University, the University of Pittsburgh, and the University of Maryland/Johns Hopkins. The study included 2,607 participants with complete data on strength training, knee pain, and radiographic evidence of knee OA (male, 44.2%; mean ± SD age 64.3 ± 9.0 years; mean ± SD body mass index 28.5 ± 4.9 kg/m² ). We used a self-administered questionnaire at the 96-month OAI visit to evaluate the exposure of strength training participation during four time periods throughout a participant's lifetime (ages 12-18, 19-34, 35-49, and ≥50 years old). The outcomes (dependent variables) were radiographic OA (ROA), symptomatic radiographic OA (SOA), and frequent knee pain.<h4>Results</h4>The fully adjusted odds ratios (95% confidence interval) for frequent knee pain, ROA, and SOA among those who participated in strength training any time in their lives were 0.82 (0.68-0.97), 0.83 (0.70-0.99), and 0.77 (0.63-0.94), respectively. Findings were similar when looking at the specific age ranges.<h4>Conclusion</h4>Strength training is beneficial for future knee health, counteracting long-held assumptions that strength training has adverse effects.2024-01-01T00:00:00Z2024 Mar2025-04-04T19:27:01.115Z2025-04-04T19:27:01.115ZS-EPMC109222763787011910.1002/art.42732