{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ishmael L"],"funding":["National Institute of Allergy and Infectious Diseases","NCATS NIH HHS","American Academy of Allergy Asthma and Immunology","NIAID NIH HHS","NIEHS NIH HHS","NHLBI NIH HHS","American Lung Association","Patient-Centered Outcomes Research Institute","Bristol Myers Squibb Foundation"],"pagination":["408-417"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10922293"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["153(2)"],"pubmed_abstract":["<h4>Background</h4>Black adults are disproportionately affected by asthma and are often considered a homogeneous group in research studies despite cultural and ancestral differences.<h4>Objective</h4>We sought to determine if asthma morbidity differs across adults in Black ethnic subgroups.<h4>Methods</h4>Adults with moderate-severe asthma were recruited across the continental United States and Puerto Rico for the PREPARE (PeRson EmPowered Asthma RElief) trial. Using self-identifications, we categorized multiethnic Black (ME/B) participants (n = 226) as Black Latinx participants (n = 146) or Caribbean, continental African, or other Black participants (n = 80). African American (AA/B) participants (n = 518) were categorized as Black participants who identified their ethnicity as being American. Baseline characteristics and retrospective asthma morbidity measures (self-reported exacerbations requiring systemic corticosteroids [SCs], emergency department/urgent care [ED/UC] visits, hospitalizations) were compared across subgroups using multivariable regression.<h4>Results</h4>Compared with AA/B participants, ME/B participants were more likely to be younger, residing in the US Northeast, and Spanish speaking and to have lower body mass index, health literacy, and <1 comorbidity, but higher blood eosinophil counts. In a multivariable analysis, ME/B participants were significantly more likely to have ED/UC visits (incidence rate ratio [IRR] = 1.34, 95% CI = 1.04-1.72) and SC use (IRR = 1.27, 95% CI = 1.00-1.62) for asthma than AA/B participants. Of the ME/B subgroups, Puerto Rican Black Latinx participants (n = 120) were significantly more likely to have ED/UC visits (IRR = 1.64, 95% CI = 1.22-2.21) and SC use for asthma (IRR = 1.43, 95% CI = 1.06-1.92) than AA/B participants. There were no significant differences in hospitalizations for asthma among subgroups.<h4>Conclusions</h4>ME/B adults, specifically Puerto Rican Black Latinx adults, have higher risk of ED/UC visits and SC use for asthma than other Black subgroups."],"journal":["The Journal of allergy and clinical immunology"],"pubmed_title":["Asthma morbidity measures across Black ethnic subgroups."],"pmcid":["PMC10922293"],"funding_grant_id":["K23AI125785","R21 HL172124","PCS-1504-30283","P30 ES013508","UM1 TR004528","K01 HL159043","AI-835475","K23 AI125785"],"pubmed_authors":["Calderon-Candelario R","Casale T","Yawn B","Mosnaim G","Carroll JK","Merriman C","Shenoy K","Riley I","Maher N","Coyne-Beasley T","Cohen R","Kaelber DC","Cui J","Hernandez P","Pinto-Plata V","Wisnivesky J","Busse PJ","Nazario S","Cardet JC","Celedon JC","Ericson B","Israel E","Apter A","Ishmael L","Phipatanakul W"],"additional_accession":[]},"is_claimable":false,"name":"Asthma morbidity measures across Black ethnic subgroups.","description":"<h4>Background</h4>Black adults are disproportionately affected by asthma and are often considered a homogeneous group in research studies despite cultural and ancestral differences.<h4>Objective</h4>We sought to determine if asthma morbidity differs across adults in Black ethnic subgroups.<h4>Methods</h4>Adults with moderate-severe asthma were recruited across the continental United States and Puerto Rico for the PREPARE (PeRson EmPowered Asthma RElief) trial. Using self-identifications, we categorized multiethnic Black (ME/B) participants (n = 226) as Black Latinx participants (n = 146) or Caribbean, continental African, or other Black participants (n = 80). African American (AA/B) participants (n = 518) were categorized as Black participants who identified their ethnicity as being American. Baseline characteristics and retrospective asthma morbidity measures (self-reported exacerbations requiring systemic corticosteroids [SCs], emergency department/urgent care [ED/UC] visits, hospitalizations) were compared across subgroups using multivariable regression.<h4>Results</h4>Compared with AA/B participants, ME/B participants were more likely to be younger, residing in the US Northeast, and Spanish speaking and to have lower body mass index, health literacy, and <1 comorbidity, but higher blood eosinophil counts. In a multivariable analysis, ME/B participants were significantly more likely to have ED/UC visits (incidence rate ratio [IRR] = 1.34, 95% CI = 1.04-1.72) and SC use (IRR = 1.27, 95% CI = 1.00-1.62) for asthma than AA/B participants. Of the ME/B subgroups, Puerto Rican Black Latinx participants (n = 120) were significantly more likely to have ED/UC visits (IRR = 1.64, 95% CI = 1.22-2.21) and SC use for asthma (IRR = 1.43, 95% CI = 1.06-1.92) than AA/B participants. There were no significant differences in hospitalizations for asthma among subgroups.<h4>Conclusions</h4>ME/B adults, specifically Puerto Rican Black Latinx adults, have higher risk of ED/UC visits and SC use for asthma than other Black subgroups.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-06-01T14:39:47.65Z","creation":"2025-04-03T23:22:14.52Z"},"accession":"S-EPMC10922293","cross_references":{"pubmed":["38000696"],"doi":["10.1016/j.jaci.2023.10.028"]}}