biostudies-literatureIshmael LNational Institute of Allergy and Infectious DiseasesNCATS NIH HHSAmerican Academy of Allergy Asthma and ImmunologyNIAID NIH HHSNIEHS NIH HHSNHLBI NIH HHSAmerican Lung AssociationPatient-Centered Outcomes Research InstituteBristol Myers Squibb Foundation408-417https://www.ebi.ac.uk/biostudies/studies/S-EPMC10922293biostudies-literatureUnknown153(2)<h4>Background</h4>Black adults are disproportionately affected by asthma and are often considered a homogeneous group in research studies despite cultural and ancestral differences.<h4>Objective</h4>We sought to determine if asthma morbidity differs across adults in Black ethnic subgroups.<h4>Methods</h4>Adults with moderate-severe asthma were recruited across the continental United States and Puerto Rico for the PREPARE (PeRson EmPowered Asthma RElief) trial. Using self-identifications, we categorized multiethnic Black (ME/B) participants (n = 226) as Black Latinx participants (n = 146) or Caribbean, continental African, or other Black participants (n = 80). African American (AA/B) participants (n = 518) were categorized as Black participants who identified their ethnicity as being American. Baseline characteristics and retrospective asthma morbidity measures (self-reported exacerbations requiring systemic corticosteroids [SCs], emergency department/urgent care [ED/UC] visits, hospitalizations) were compared across subgroups using multivariable regression.<h4>Results</h4>Compared with AA/B participants, ME/B participants were more likely to be younger, residing in the US Northeast, and Spanish speaking and to have lower body mass index, health literacy, and <1 comorbidity, but higher blood eosinophil counts. In a multivariable analysis, ME/B participants were significantly more likely to have ED/UC visits (incidence rate ratio [IRR] = 1.34, 95% CI = 1.04-1.72) and SC use (IRR = 1.27, 95% CI = 1.00-1.62) for asthma than AA/B participants. Of the ME/B subgroups, Puerto Rican Black Latinx participants (n = 120) were significantly more likely to have ED/UC visits (IRR = 1.64, 95% CI = 1.22-2.21) and SC use for asthma (IRR = 1.43, 95% CI = 1.06-1.92) than AA/B participants. There were no significant differences in hospitalizations for asthma among subgroups.<h4>Conclusions</h4>ME/B adults, specifically Puerto Rican Black Latinx adults, have higher risk of ED/UC visits and SC use for asthma than other Black subgroups.The Journal of allergy and clinical immunologyAsthma morbidity measures across Black ethnic subgroups.PMC10922293K23AI125785R21 HL172124PCS-1504-30283P30 ES013508UM1 TR004528K01 HL159043AI-835475K23 AI125785Calderon-Candelario RCasale TYawn BMosnaim GCarroll JKMerriman CShenoy KRiley IMaher NCoyne-Beasley TCohen RKaelber DCCui JHernandez PPinto-Plata VWisnivesky JBusse PJNazario SCardet JCCeledon JCEricson BIsrael EApter AIshmael LPhipatanakul WfalseAsthma morbidity measures across Black ethnic subgroups.<h4>Background</h4>Black adults are disproportionately affected by asthma and are often considered a homogeneous group in research studies despite cultural and ancestral differences.<h4>Objective</h4>We sought to determine if asthma morbidity differs across adults in Black ethnic subgroups.<h4>Methods</h4>Adults with moderate-severe asthma were recruited across the continental United States and Puerto Rico for the PREPARE (PeRson EmPowered Asthma RElief) trial. Using self-identifications, we categorized multiethnic Black (ME/B) participants (n = 226) as Black Latinx participants (n = 146) or Caribbean, continental African, or other Black participants (n = 80). African American (AA/B) participants (n = 518) were categorized as Black participants who identified their ethnicity as being American. Baseline characteristics and retrospective asthma morbidity measures (self-reported exacerbations requiring systemic corticosteroids [SCs], emergency department/urgent care [ED/UC] visits, hospitalizations) were compared across subgroups using multivariable regression.<h4>Results</h4>Compared with AA/B participants, ME/B participants were more likely to be younger, residing in the US Northeast, and Spanish speaking and to have lower body mass index, health literacy, and <1 comorbidity, but higher blood eosinophil counts. In a multivariable analysis, ME/B participants were significantly more likely to have ED/UC visits (incidence rate ratio [IRR] = 1.34, 95% CI = 1.04-1.72) and SC use (IRR = 1.27, 95% CI = 1.00-1.62) for asthma than AA/B participants. Of the ME/B subgroups, Puerto Rican Black Latinx participants (n = 120) were significantly more likely to have ED/UC visits (IRR = 1.64, 95% CI = 1.22-2.21) and SC use for asthma (IRR = 1.43, 95% CI = 1.06-1.92) than AA/B participants. There were no significant differences in hospitalizations for asthma among subgroups.<h4>Conclusions</h4>ME/B adults, specifically Puerto Rican Black Latinx adults, have higher risk of ED/UC visits and SC use for asthma than other Black subgroups.2024-01-01T00:00:00Z2024 Feb2026-06-01T14:39:47.65Z2025-04-03T23:22:14.52ZS-EPMC109222933800069610.1016/j.jaci.2023.10.028