{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen N"],"funding":["National Cancer Institute","NCI NIH HHS","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["419-425"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10922505"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(3)"],"pubmed_abstract":["<h4>Background</h4>Studies have shown improved survival among individuals with cancer with higher levels of social support. Few studies have investigated social support and overall survival (OS) in individuals with advanced prostate cancer in an international cohort. We investigated the associations of marital status and living arrangements with OS among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer (IRONMAN).<h4>Methods</h4>IRONMAN is enrolling participants diagnosed with advanced prostate cancer (metastatic hormone-sensitive prostate cancer, mHSPC; castration-resistant prostate cancer, CRPC) from 16 countries. Participants in this analysis were recruited between July 2017 and January 2023. Adjusting for demographics and tumor characteristics, the associations were estimated using Cox regression and stratified by disease state (mHSPC, CRPC), age (<70, ≥70 years), and continent of enrollment (North America, Europe, Other).<h4>Results</h4>We included 2,119 participants with advanced prostate cancer, of whom 427 died during up to 5 years of follow-up (median 6 months). Two-thirds had mHSPC. Most were married/in a civil partnership (79%) and 6% were widowed. Very few married participants were living alone (1%), while most unmarried participants were living alone (70%). Married participants had better OS than unmarried participants [adjusted HR: 1.44; 95% confidence interval (CI): 1.02-2.02]. Widowed participants had the worst survival compared with married individuals (adjusted HR: 1.89; 95% CI: 1.22-2.94).<h4>Conclusions</h4>Among those with advanced prostate cancer, unmarried and widowed participants had worse OS compared with married participants.<h4>Impact</h4>This research highlighted the importance of social support in OS within this vulnerable population."],"journal":["Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology"],"pubmed_title":["Marital Status, Living Arrangement, and Survival among Individuals with Advanced Prostate Cancer in the International Registry for Men with Advanced Prostate Cancer."],"pmcid":["PMC10922505"],"funding_grant_id":["T32GM007753","T32 GM144273","P30 CA008748","T32 GM007753","T32GM144273","F30 CA264965","F30CA264965"],"pubmed_authors":["Nowak J","George DJ","Chi KN","Anderson SG","Badal SAM","McDermott R","Popoola AA","Cheng HH","Mateo J","Esteban E","Enting D","Fay AP","Henegan JC","Stopsack KH","Hyslop T","Ericsson CI","Bitting RL","Omlin A","Davis ID","Vaselkiv JB","Guard HE","Chen N","Ragin C","Autio KA","Kantoff PW","IRONMAN Registry","McGrath CB","Rathkopf DE","Heath EI","Gerke T","Russnes KM","Mucci LA","Pomerantz MM","Bjartell A","Penney KL","Rencsok EM","Githiaka CW"],"additional_accession":[]},"is_claimable":false,"name":"Marital Status, Living Arrangement, and Survival among Individuals with Advanced Prostate Cancer in the International Registry for Men with Advanced Prostate Cancer.","description":"<h4>Background</h4>Studies have shown improved survival among individuals with cancer with higher levels of social support. Few studies have investigated social support and overall survival (OS) in individuals with advanced prostate cancer in an international cohort. We investigated the associations of marital status and living arrangements with OS among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer (IRONMAN).<h4>Methods</h4>IRONMAN is enrolling participants diagnosed with advanced prostate cancer (metastatic hormone-sensitive prostate cancer, mHSPC; castration-resistant prostate cancer, CRPC) from 16 countries. Participants in this analysis were recruited between July 2017 and January 2023. Adjusting for demographics and tumor characteristics, the associations were estimated using Cox regression and stratified by disease state (mHSPC, CRPC), age (<70, ≥70 years), and continent of enrollment (North America, Europe, Other).<h4>Results</h4>We included 2,119 participants with advanced prostate cancer, of whom 427 died during up to 5 years of follow-up (median 6 months). Two-thirds had mHSPC. Most were married/in a civil partnership (79%) and 6% were widowed. Very few married participants were living alone (1%), while most unmarried participants were living alone (70%). Married participants had better OS than unmarried participants [adjusted HR: 1.44; 95% confidence interval (CI): 1.02-2.02]. Widowed participants had the worst survival compared with married individuals (adjusted HR: 1.89; 95% CI: 1.22-2.94).<h4>Conclusions</h4>Among those with advanced prostate cancer, unmarried and widowed participants had worse OS compared with married participants.<h4>Impact</h4>This research highlighted the importance of social support in OS within this vulnerable population.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-19T20:39:16.167Z","creation":"2025-04-19T20:39:16.167Z"},"accession":"S-EPMC10922505","cross_references":{"pubmed":["38189661"],"doi":["10.1158/1055-9965.epi-23-1207","10.1158/1055-9965.EPI-23-1207"]}}