biostudies-literatureEl-Achkar TMNIDDK NIH HHSNational Institutes of Health402-410https://www.ebi.ac.uk/biostudies/studies/S-EPMC10922684biostudies-literatureUnknown83(3)Chronic kidney disease (CKD) and acute kidney injury (AKI) are heterogeneous syndromes defined clinically by serial measures of kidney function. Each condition possesses strong histopathologic associations, including glomerular obsolescence or acute tubular necrosis, respectively. Despite such characterization, there remains wide variation in patient outcomes and treatment responses. Precision medicine efforts, as exemplified by the Kidney Precision Medicine Project (KPMP), have begun to establish evolving, spatially anchored, cellular and molecular atlases of the cell types, states, and niches of the kidney in health and disease. The KPMP atlas provides molecular context for CKD and AKI disease drivers and will help define subtypes of disease that are not readily apparent from canonical functional or histopathologic characterization but instead are appreciable through advanced clinical phenotyping, pathomic, transcriptomic, proteomic, epigenomic, and metabolomic interrogation of kidney biopsy samples. This perspective outlines the structure of the KPMP, its approach to the integration of these diverse datasets, and its major outputs relevant to future patient care.American journal of kidney diseases : the official journal of the National Kidney FoundationPrecision Medicine in Nephrology: An Integrative Framework of Multidimensional Data in the Kidney Precision Medicine Project.PMC10922684U01 DK114923R21 DK126329U01 DK133090U24 DK114886Bernard LOtto EYoung BDiettman SMVictoria Castro AMWilliams KTaliercio JWilliams JVenkatachalam MWright ZFlanagan SAppelbaum PLardenoije RCrawford DDemeke DPillai ASutton TWilson FPKiryluk KPatel MBarwinska DPatel JAdeyi OJain SHe CKoewler RBender FHe JBorner KBasta JKlett SCarson JBledsoe SRike AGoltsev YJain YSambandam KYadati PKudose SEadon MRennke HKelly TLimonte CD'Agati VParikh SAlakwaa FSnyder JYu GKendrick JLecker SKaushal MPyle LFroment AParikh CWinfree SMcMahon GTokita JLienczewski CPoggio EKelly KCheng YHBeyda DHerr BMurugan RCarmona-Powell Ron Gaba EMeza NVan de Plas RRecord EDagher PMarquez NTuttle KLee SCOnul ILukowski JO'Toole JSchaub JMaikhor SSafadi SIlori TWoodle ESKellum JAFerkowicz MYe HEadon MTHenderson-Brown Jerica Berge DHerlitz LRosengart MDowd FRao VCaprioli RMAulisio MSaunders MPhuong JDaniel Sde Pinho Goncalves JXiong YVerma ANadkarni GCorona Villalobos CPRovin BChen YChen SAsghari MBrosius FDufresne MSendrey DRedmond DSharma KBebiak JCampos BTsosie RThurman JHoofnagle AArora TDunn KBarasch JO'Malley CCanetta PAJolly SIyengar SRPalevsky PMooney SCai QViswanathan VSMehl KHimmelfarb JMa SSharman KSedor JBowen WNam Yde Caestecker MMigas LFogo ATroyanskaya OHarindhanavudhi TColona MRGisch DLKnoten AWilcox AScott RMao WBui JMariani Lde Boer IHMinor BSteck BWangperawong AHe YOMenon RWolf SMukatash TSealfon RDighe ALShpigel AAnjani KGadegbeku CSabatello MArdayfio JLarson BLuo JEl-Achkar TMMiller RTBalderes OQuardokus EHartman JBerglund AZhang GCooperman LCoca SZhang DZhang KOliver GConlon KMoeckel GShi TPasa-Tolic LJefferson NFox MBitzer MMadhavan SMWrobel JAmodu AASlade APollack AKermani AZhang BFarrow MRezaei KColeman ALake BBeck LSetty SRosas SHenderson JCantley LHacohen NGilliam MFrey RSaul JAscani HBerroue CThajudeen BGrewenow SMVelickovic DChaudhury Evan Zeitler PRTublin MMcClelland RBalis UNachman PKidney Precision Medicine ProjectCheng YDull RHodgin JShaw MHsieh EBlanc VKelley SShankland STorrealba JAnderton CMcCown PAlloway RRLash JHoover PJBlank KLefferts SKnight RBream PBush LAllen JBush WWoodhead GRoberts GWen YMendoza KBansal SAzeloglu EWang ABracamonte EMenez SPrasad PSchmidt IMorales ANolan GWang NKakade VShang NRenteria AAlpers CGreka ABogen SConser NWen NLaszik ZGCaramori MLSarkisova NWinters JMarshall JLNwanne GElder MSun JLucarelli NMoledina DPark HHendricks AVinovskis CBerry BEddy SHedayati SAtta MGinley BDonohoe IWaikar SSpates-Harden KKretzler MToto RDGaut JJohansen CSabo ABjornstad PPinkeney RPark CTan RSpraggins JLee PJRicardo AHall DEMottl ASarder PWard SSrivastava ANair VEl-Achkar TVerdoes AXu ADjambazova KPamreddy AStutzke CFerreira RMMontellano RWofford SRose MCampbell TBomback ABonevich NShapiro JPMoe OWMadabhushi ABasit MNguyen JReamy RVazquez MPalmer ECampbell KBrown KVijayan AfalsePrecision Medicine in Nephrology: An Integrative Framework of Multidimensional Data in the Kidney Precision Medicine Project.Chronic kidney disease (CKD) and acute kidney injury (AKI) are heterogeneous syndromes defined clinically by serial measures of kidney function. Each condition possesses strong histopathologic associations, including glomerular obsolescence or acute tubular necrosis, respectively. Despite such characterization, there remains wide variation in patient outcomes and treatment responses. Precision medicine efforts, as exemplified by the Kidney Precision Medicine Project (KPMP), have begun to establish evolving, spatially anchored, cellular and molecular atlases of the cell types, states, and niches of the kidney in health and disease. The KPMP atlas provides molecular context for CKD and AKI disease drivers and will help define subtypes of disease that are not readily apparent from canonical functional or histopathologic characterization but instead are appreciable through advanced clinical phenotyping, pathomic, transcriptomic, proteomic, epigenomic, and metabolomic interrogation of kidney biopsy samples. This perspective outlines the structure of the KPMP, its approach to the integration of these diverse datasets, and its major outputs relevant to future patient care.2024-01-01T00:00:00Z2024 Mar2025-04-22T18:56:56.527Z2025-04-06T02:35:28.306ZS-EPMC109226843783968810.1053/j.ajkd.2023.08.015