{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Midya V"],"funding":["National Institute of Environmental Health Sciences","National Center for Advancing Translational Sciences","NCATS NIH HHS","NIEHS NIH HHS","National Institutes of Health","NIH HHS","Icahn School of Medicine at Mount Sinai"],"pagination":["170361"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10922719"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["916"],"pubmed_abstract":["<h4>Background</h4>Childhood depression is a major public health issue worldwide. Previous studies have linked both prenatal metal exposures and the gut microbiome to depression in children. However, few, if any, have studied their interacting effect in specific subgroups of children.<h4>Objectives</h4>Using an interpretable machine-learning method, this study investigates whether children with specific combinations of prenatal metals and childhood microbial signatures (cliques or groups of metals and microbes) were more likely to have higher depression scores at 9-11 years of age.<h4>Methods</h4>We leveraged data from a well-characterized pediatric longitudinal birth cohort in Mexico City and its microbiome substudy (n = 112). Eleven metal exposures were measured in maternal whole blood s"],"journal":["The Science of the total environment"],"pubmed_title":["Prenatal metal exposures and childhood gut microbial signatures are associated with depression score in late childhood."],"pmcid":["PMC10922719"],"funding_grant_id":["R00 ES032884","S10 OD030463","R00ES032884","P30 ES005605","P30ES023515","S10 OD026880","UL1 TR004419","R01 ES013744","R01ES013744","U2C ES026555","S10OD030463","S10OD026880","P30 ES023515","R35ES030435","U2CES026555","UL1TR004419","R35 ES030435"],"pubmed_authors":["Midya V","Torres-Calapiz M","Arora M","Tellez-Rojo MM","Nagdeo K","Gennings C","Lane JM","Torres-Olascoaga LA","Horton MK","Eggers S","Wright RO"],"additional_accession":[]},"is_claimable":false,"name":"Prenatal metal exposures and childhood gut microbial signatures are associated with depression score in late childhood.","description":"<h4>Background</h4>Childhood depression is a major public health issue worldwide. Previous studies have linked both prenatal metal exposures and the gut microbiome to depression in children. However, few, if any, have studied their interacting effect in specific subgroups of children.<h4>Objectives</h4>Using an interpretable machine-learning method, this study investigates whether children with specific combinations of prenatal metals and childhood microbial signatures (cliques or groups of metals and microbes) were more likely to have higher depression scores at 9-11 years of age.<h4>Methods</h4>We leveraged data from a well-characterized pediatric longitudinal birth cohort in Mexico City and its microbiome substudy (n = 112). Eleven metal exposures were measured in maternal whole blood s","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-06-01T05:39:29.512Z","creation":"2025-04-04T09:06:58.172Z"},"accession":"S-EPMC10922719","cross_references":{"pubmed":["38278245"],"doi":["10.1016/j.scitotenv.2024.170361"]}}