{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cherkos AS"],"funding":["NIAID NIH HHS"],"pagination":["537-546"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10922740"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(4)"],"pubmed_abstract":["<h4>Background</h4>Exposure to HIV and antiretroviral therapy (ART) in utero may influence infant growth and development. Most available evidence predates adoption of universal ART (Option B+ ART regimens). In a recent cohort, we compared growth and development in HIV-exposed uninfected (HEU) to HIV-unexposed (HUU) infants.<h4>Design</h4>Prospective cohort study: data from Impact of Maternal HIV on Mycobacterium Tuberculosis Infection among Peripartum Women and their Infants (MiTIPS) in Western Kenya.<h4>Methods</h4>Women were enrolled during pregnancy. Mother-infant pairs were followed until 24 months postpartum. We used multivariable linear mixed-effects models to compare growth rates [weight-for-age z score (WAZ) and height-for-age z score (HAZ)] and multivariable linear regression to compare overall development between HEU and HUU children.<h4>Results</h4>About 51.8% (184/355) of the infants were HEU, 3.9% low birthweight (<2.5 kg), and 8.5% preterm (<37 gestational weeks). During pregnancy, all mothers of HEU received ART; 67.9% started ART prepregnancy, and 87.3% received 3TC/FTC, TDF, and EFV. In longitudinal analyses, HEU children did not differ significantly from HUU in growth or development ( P  > 0.05 for all). In the combined HEU/HUU cohort, higher maternal education was associated with significantly better growth and development: WAZ [ β  = 0.18 (95% CI 0.01-0.34)], HAZ [ β  = 0.26 (95% CI 0.04-0.48)], and development [ β  = 0.24 (95% CI 0.02-0.46)]. Breastfeeding was associated with significantly better HAZ [ β =0.42 (95% CI 0.19-0.66)] and development [ β  =0.31 (95% CI 0.08-0.53)].<h4>Conclusion</h4>HEU children in the setting of universal maternal ART had a similar growth trajectory and development to HUU children. Breastfeeding and maternal education improved children's weight, height, and overall development irrespective of maternal HIV status."],"journal":["AIDS (London, England)"],"pubmed_title":["Maternal breastfeeding and education impact infant growth and development more than in-utero HIV/antiretroviral therapy exposure in context of universal antiretroviral therapy."],"pmcid":["PMC10922740"],"funding_grant_id":["K23 AI120793","R01 AI142647"],"pubmed_authors":["Enquobahrie DA","LaCourse SM","Escudero JN","Mecha J","Kinuthia J","John-Stewart G","Cherkos AS"],"additional_accession":[]},"is_claimable":false,"name":"Maternal breastfeeding and education impact infant growth and development more than in-utero HIV/antiretroviral therapy exposure in context of universal antiretroviral therapy.","description":"<h4>Background</h4>Exposure to HIV and antiretroviral therapy (ART) in utero may influence infant growth and development. Most available evidence predates adoption of universal ART (Option B+ ART regimens). In a recent cohort, we compared growth and development in HIV-exposed uninfected (HEU) to HIV-unexposed (HUU) infants.<h4>Design</h4>Prospective cohort study: data from Impact of Maternal HIV on Mycobacterium Tuberculosis Infection among Peripartum Women and their Infants (MiTIPS) in Western Kenya.<h4>Methods</h4>Women were enrolled during pregnancy. Mother-infant pairs were followed until 24 months postpartum. We used multivariable linear mixed-effects models to compare growth rates [weight-for-age z score (WAZ) and height-for-age z score (HAZ)] and multivariable linear regression to compare overall development between HEU and HUU children.<h4>Results</h4>About 51.8% (184/355) of the infants were HEU, 3.9% low birthweight (<2.5 kg), and 8.5% preterm (<37 gestational weeks). During pregnancy, all mothers of HEU received ART; 67.9% started ART prepregnancy, and 87.3% received 3TC/FTC, TDF, and EFV. In longitudinal analyses, HEU children did not differ significantly from HUU in growth or development ( P  > 0.05 for all). In the combined HEU/HUU cohort, higher maternal education was associated with significantly better growth and development: WAZ [ β  = 0.18 (95% CI 0.01-0.34)], HAZ [ β  = 0.26 (95% CI 0.04-0.48)], and development [ β  = 0.24 (95% CI 0.02-0.46)]. Breastfeeding was associated with significantly better HAZ [ β =0.42 (95% CI 0.19-0.66)] and development [ β  =0.31 (95% CI 0.08-0.53)].<h4>Conclusion</h4>HEU children in the setting of universal maternal ART had a similar growth trajectory and development to HUU children. Breastfeeding and maternal education improved children's weight, height, and overall development irrespective of maternal HIV status.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-03T23:57:13.291Z","creation":"2025-04-03T23:57:13.291Z"},"accession":"S-EPMC10922740","cross_references":{"pubmed":["37967230"],"doi":["10.1097/qad.0000000000003785","10.1097/QAD.0000000000003785"]}}